Names & Taxonomy
- Uniprot ID:
- P19438
- Entry Name:
- TNR1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
- Gene Names:
- TNFRSF1A TNFAR TNFR1
- Gene Names Primary:
- TNFRSF1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 455
- Sequence:
- MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
- Gene Ontology Go:
- cell surface
extracellular region
extracellular space
Golgi membrane
integral component of plasma membrane
membrane raft
mitochondrion
plasma membrane
receptor complex
identical protein binding
tumor necrosis factor binding
tumor necrosis factor-activated receptor activity
cell surface receptor signaling pathway
cellular response to mechanical stimulus
cytokine-mediated signaling pathway
death-inducing signaling complex assembly
defense response to bacterium
establishment of protein localization to plasma membrane
extrinsic apoptotic signaling pathway via death domain receptors
I-kappaB kinase/NF-kappaB signaling
immune response
inflammatory response
intrinsic apoptotic signaling pathway in response to DNA damage
multicellular organism development
negative regulation of inflammatory response
positive regulation of ceramide biosynthetic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of inflammatory response
positive regulation of transcription from RNA polymerase II promoter
positive regulation of tyrosine phosphorylation of Stat1 protein
prostaglandin metabolic process
regulation of apoptotic process
regulation of cell proliferation
regulation of establishment of endothelial barrier
regulation of tumor necrosis factor-mediated signaling pathway
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
viral process - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
cellular response to mechanical stimulus
cytokine-mediated signaling pathway
death-inducing signaling complex assembly
defense response to bacterium
establishment of protein localization to plasma membrane
extrinsic apoptotic signaling pathway via death domain receptors
I-kappaB kinase/NF-kappaB signaling
immune response
inflammatory response
intrinsic apoptotic signaling pathway in response to DNA damage
multicellular organism development
negative regulation of inflammatory response
positive regulation of ceramide biosynthetic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of inflammatory response
positive regulation of transcription from RNA polymerase II promoter
positive regulation of tyrosine phosphorylation of Stat1 protein
prostaglandin metabolic process
regulation of apoptotic process
regulation of cell proliferation
regulation of establishment of endothelial barrier
regulation of tumor necrosis factor-mediated signaling pathway
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
viral process - Gene Ontology Molecular Function:
- identical protein binding
tumor necrosis factor-activated receptor activity
tumor necrosis factor binding - Gene Ontology Cellular Component:
- cell surface
extracellular region
extracellular space
Golgi membrane
integral component of plasma membrane
membrane raft
mitochondrion
plasma membrane
receptor complex - Keywords:
- 3D-structure
Alternative splicing
Amyloidosis
Apoptosis
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Golgi apparatus
Host-virus interaction
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P28799; Q13546; P01375; Q15628; Q12933