Names & Taxonomy
- Uniprot ID:
- P19235
- Entry Name:
- EPOR_HUMAN
- Status:
- reviewed
- Protein Names:
- Erythropoietin receptor (EPO-R)
- Gene Names:
- EPOR
- Gene Names Primary:
- EPOR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 508
- Sequence:
- MDHLGASLWPQVGSLCLLLAGAAWAPPPNLPDPKFESKAALLAARGPEELLCFTERLEDLVCFWEEAASAGVGPGNYSFSYQLEDEPWKLCRLHQAPTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYHRVIHINEVVLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGRTECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLDPLILTLSLILVVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWWSPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLPRNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLRPWTLCPELPPTPPHLKYLYLVVSDSGISTDYSSGDSQGAQGGLSDGPYSNPYENSLIPAAEPLPPSYVACS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein.; Isoform EPOR-S: Secreted
Function
- Function:
- Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.; Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
- Cross Reference Drug Bank:
- DB00012 DB00016 DB08923 DB08894
- Gene Ontology Go:
- cytosol
external side of plasma membrane
extracellular region
integral component of plasma membrane
erythropoietin receptor activity
identical protein binding
brain development
decidualization
erythropoietin-mediated signaling pathway
heart development
negative regulation of hydrogen peroxide-induced cell death
negative regulation of neuron apoptotic process
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of ERK1 and ERK2 cascade
positive regulation of neuron projection development
signal transduction - Gene Ontology Biological Process:
- brain development
decidualization
erythropoietin-mediated signaling pathway
heart development
negative regulation of hydrogen peroxide-induced cell death
negative regulation of neuron apoptotic process
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of ERK1 and ERK2 cascade
positive regulation of neuron projection development
signal transduction - Gene Ontology Molecular Function:
- erythropoietin receptor activity
identical protein binding - Gene Ontology Cellular Component:
- cytosol
external side of plasma membrane
extracellular region
integral component of plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Congenital erythrocytosis
Disease mutation
Disulfide bond
Glycoprotein
Isopeptide bond
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- Itself; Q8WWM7; Q62225; P01588; P16885; P18031; P29350; O14508