Names & Taxonomy
- Uniprot ID:
- P18858
- Entry Name:
- DNLI1_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1)
- Gene Names:
- LIG1
- Gene Names Primary:
- LIG1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 919
- Sequence:
- MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDTY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
- Catalytic Activity:
- ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 568 568 N6-AMP-lysine intermediate.
- Cross Reference Drug Bank:
- DB00290
- Gene Ontology Go:
- Golgi apparatus
intracellular membrane-bounded organelle
mitochondrion
nucleoplasm
nucleus
ATP binding
DNA binding
DNA ligase (ATP) activity
DNA ligase activity
metal ion binding
anatomical structure morphogenesis
base-excision repair
cell division
DNA biosynthetic process
DNA ligation
DNA metabolic process
DNA repair
DNA strand elongation involved in DNA replication
global genome nucleotide-excision repair
mismatch repair
mitotic cell cycle
nucleotide-excision repair
nucleotide-excision repair, DNA gap filling
Okazaki fragment processing involved in mitotic DNA replication
telomere maintenance
telomere maintenance via recombination
telomere maintenance via semi-conservative replication
transcription-coupled nucleotide-excision repair - Gene Ontology Biological Process:
- anatomical structure morphogenesis
base-excision repair
cell division
DNA biosynthetic process
DNA ligation
DNA metabolic process
DNA repair
DNA strand elongation involved in DNA replication
global genome nucleotide-excision repair
mismatch repair
mitotic cell cycle
nucleotide-excision repair
nucleotide-excision repair, DNA gap filling
Okazaki fragment processing involved in mitotic DNA replication
telomere maintenance
telomere maintenance via recombination
telomere maintenance via semi-conservative replication
transcription-coupled nucleotide-excision repair - Gene Ontology Molecular Function:
- ATP binding
DNA binding
DNA ligase (ATP) activity
DNA ligase activity
metal ion binding - Gene Ontology Cellular Component:
- Golgi apparatus
intracellular membrane-bounded organelle
mitochondrion
nucleoplasm
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell cycle
Cell division
Complete proteome
DNA damage
DNA recombination
DNA repair
DNA replication
Isopeptide bond
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation