Names & Taxonomy

Uniprot ID:
P18858
Entry Name:
DNLI1_HUMAN
Status:
reviewed
Protein Names:
DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1)
Gene Names:
LIG1
Gene Names Primary:
LIG1
Organism:
Homo sapiens (Human)

Structure

Length:
919
Sequence:
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDTY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus.

Function

Function:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Catalytic Activity:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Active Site:
ACT_SITE 568 568 N6-AMP-lysine intermediate.
Cross Reference Drug Bank:
DB00290
Gene Ontology Go:
Golgi apparatus
intracellular membrane-bounded organelle
mitochondrion
nucleoplasm
nucleus
ATP binding
DNA binding
DNA ligase (ATP) activity
DNA ligase activity
metal ion binding
anatomical structure morphogenesis
base-excision repair
cell division
DNA biosynthetic process
DNA ligation
DNA metabolic process
DNA repair
DNA strand elongation involved in DNA replication
global genome nucleotide-excision repair
mismatch repair
mitotic cell cycle
nucleotide-excision repair
nucleotide-excision repair, DNA gap filling
Okazaki fragment processing involved in mitotic DNA replication
telomere maintenance
telomere maintenance via recombination
telomere maintenance via semi-conservative replication
transcription-coupled nucleotide-excision repair
Gene Ontology Biological Process:
anatomical structure morphogenesis
base-excision repair
cell division
DNA biosynthetic process
DNA ligation
DNA metabolic process
DNA repair
DNA strand elongation involved in DNA replication
global genome nucleotide-excision repair
mismatch repair
mitotic cell cycle
nucleotide-excision repair
nucleotide-excision repair, DNA gap filling
Okazaki fragment processing involved in mitotic DNA replication
telomere maintenance
telomere maintenance via recombination
telomere maintenance via semi-conservative replication
transcription-coupled nucleotide-excision repair
Gene Ontology Molecular Function:
ATP binding
DNA binding
DNA ligase (ATP) activity
DNA ligase activity
metal ion binding
Gene Ontology Cellular Component:
Golgi apparatus
intracellular membrane-bounded organelle
mitochondrion
nucleoplasm
nucleus
Keywords:
3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell cycle
Cell division
Complete proteome
DNA damage
DNA recombination
DNA repair
DNA replication
Isopeptide bond
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation

Publication

PubMed ID:
2204063 14702039 15057824 15489334 1881902 17081983 16964243 17693683 18669648 18655026 19413330 19690332 20068231 21269460 21406692 24911150 15565146 1581963 16959974