Names & Taxonomy
- Uniprot ID:
- P18846
- Entry Name:
- ATF1_HUMAN
- Status:
- reviewed
- Protein Names:
- Cyclic AMP-dependent transcription factor ATF-1 (cAMP-dependent transcription factor ATF-1) (Activating transcription factor 1) (Protein TREB36)
- Gene Names:
- ATF1
- Gene Names Primary:
- ATF1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 271
- Sequence:
- MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
- Cross Reference Drug Bank:
- DB00852
- Gene Ontology Go:
- ATF1-ATF4 transcription factor complex
nucleoplasm
nucleus
RNA polymerase II regulatory region sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
cellular protein complex assembly
innate immune response
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
neurotrophin TRK receptor signaling pathway
positive regulation of DNA replication
positive regulation of neuron projection development
positive regulation of transcription from RNA polymerase II promoter
response to cobalt ion
response to organic cyclic compound
stress-activated MAPK cascade
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
transcription from RNA polymerase II promoter
TRIF-dependent toll-like receptor signaling pathway - Gene Ontology Biological Process:
- cellular protein complex assembly
innate immune response
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
neurotrophin TRK receptor signaling pathway
positive regulation of DNA replication
positive regulation of neuron projection development
positive regulation of transcription from RNA polymerase II promoter
response to cobalt ion
response to organic cyclic compound
stress-activated MAPK cascade
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
transcription from RNA polymerase II promoter
TRIF-dependent toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, sequence-specific DNA binding - Gene Ontology Cellular Component:
- ATF1-ATF4 transcription factor complex
nucleoplasm
nucleus - Keywords:
- Activator
Alternative splicing
Chromosomal rearrangement
Complete proteome
DNA-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation - Interacts With:
- P03259-2; P16220; P0C746; P05412; Q9DGW5; O95644; Q16649