Names & Taxonomy
- Uniprot ID:
- P18505
- Entry Name:
- GBRB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1)
- Gene Names:
- GABRB1
- Gene Names Primary:
- GABRB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 474
- Sequence:
- MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
- Cross Reference Drug Bank:
- DB00659 DB00546 DB00404 DB00543 DB01558 DB00237 DB00241 DB00475 DB01594 DB00349 DB01068 DB00628 DB01559 DB01189 DB00829 DB00228 DB01049 DB01215 DB00402 DB00898 DB00189 DB00292 DB01567 DB01205 DB00690 DB01440 DB01437 DB00801 DB01159 DB00753 DB01587 DB00431 DB00186 DB00371 DB01028 DB01107 DB00683 DB01595 DB00334 DB00842 DB00312 DB01588 DB00794 DB00818 DB01589 DB01236 DB00306 DB00231 DB00273 DB00897
- Gene Ontology Go:
- cell junction
chloride channel complex
cytoplasm
dendrite
GABA-A receptor complex
integral component of plasma membrane
nuclear envelope
plasma membrane
postsynaptic membrane
chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity
ligand-gated ion channel activity
cellular response to histamine
central nervous system neuron development
ion transmembrane transport
ion transport
ovulation cycle
response to progesterone
response to toxic substance
signal transduction
synaptic transmission
transmembrane transport
transport - Gene Ontology Biological Process:
- cellular response to histamine
central nervous system neuron development
ion transmembrane transport
ion transport
ovulation cycle
response to progesterone
response to toxic substance
signal transduction
synaptic transmission
transmembrane transport
transport - Gene Ontology Molecular Function:
- chloride channel activity
extracellular ligand-gated ion channel activity
GABA-A receptor activity
ligand-gated ion channel activity - Gene Ontology Cellular Component:
- cell junction
chloride channel complex
cytoplasm
dendrite
GABA-A receptor complex
integral component of plasma membrane
nuclear envelope
plasma membrane
postsynaptic membrane - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Chloride
Chloride channel
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport