Names & Taxonomy
- Uniprot ID:
- P17858
- Entry Name:
- PFKAL_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)
- Gene Names:
- PFKL
- Gene Names Primary:
- PFKL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 780
- Sequence:
- MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
- Pathway:
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.
- Catalytic Activity:
- ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. GlcNAcylation by OGT overcomes allosteric regulation.
- Active Site:
- ACT_SITE 166 166 Proton acceptor.
- Gene Ontology Go:
- 6-phosphofructokinase complex
cytosol
extracellular exosome
membrane
6-phosphofructokinase activity
ATP binding
fructose binding
fructose-6-phosphate binding
identical protein binding
kinase binding
metal ion binding
canonical glycolysis
carbohydrate metabolic process
fructose 1,6-bisphosphate metabolic process
fructose 6-phosphate metabolic process
glucose metabolic process
glycolytic process
negative regulation of insulin secretion
protein homotetramerization
protein oligomerization
response to glucose
small molecule metabolic process - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
fructose 1,6-bisphosphate metabolic process
fructose 6-phosphate metabolic process
glucose metabolic process
glycolytic process
negative regulation of insulin secretion
protein homotetramerization
protein oligomerization
response to glucose
small molecule metabolic process - Gene Ontology Molecular Function:
- 6-phosphofructokinase activity
ATP binding
fructose-6-phosphate binding
fructose binding
identical protein binding
kinase binding
metal ion binding - Gene Ontology Cellular Component:
- 6-phosphofructokinase complex
cytosol
extracellular exosome
membrane - Keywords:
- ATP-binding
Acetylation
Allosteric enzyme
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Glycolysis
Glycoprotein
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- Itself; Q969Y2; P60409; P26371; P08237