Names & Taxonomy

Uniprot ID:
P17812
Entry Name:
PYRG1_HUMAN
Status:
reviewed
Protein Names:
CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1)
Gene Names:
CTPS1 CTPS
Gene Names Primary:
CTPS1
Organism:
Homo sapiens (Human)

Structure

Length:
591
Sequence:
MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD
Proteomes:
UP000005640

Function

Function:
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
Pathway:
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.
Catalytic Activity:
ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.
Enzyme Regulation:
ENZYME REGULATION: Activated by GTP and inhibited by CTP.
Active Site:
ACT_SITE 399 399 For GATase activity.
Cross Reference Drug Bank:
DB00130
Gene Ontology Go:
cytosol
membrane
ATP binding
CTP synthase activity
'de novo' CTP biosynthetic process
B cell proliferation
CTP biosynthetic process
glutamine metabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
response to drug
small molecule metabolic process
T cell proliferation
Gene Ontology Biological Process:
'de novo' CTP biosynthetic process
B cell proliferation
CTP biosynthetic process
glutamine metabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
response to drug
small molecule metabolic process
T cell proliferation
Gene Ontology Molecular Function:
ATP binding
CTP synthase activity
Gene Ontology Cellular Component:
cytosol
membrane
Keywords:
3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Glutamine amidotransferase
Immunity
Ligase
Nucleotide-binding
Phosphoprotein
Polymorphism
Pyrimidine biosynthesis
Reference proteome

Publication

PubMed ID:
2113467 14702039 16710414 15489334 16179339 17081983 16964243 17487921 18220336 18088087 18691976 18669648 19413330 19690332 19608861 20068231 21269460 21406692 24870241 16820675