Names & Taxonomy
- Uniprot ID:
- P17812
- Entry Name:
- PYRG1_HUMAN
- Status:
- reviewed
- Protein Names:
- CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1)
- Gene Names:
- CTPS1 CTPS
- Gene Names Primary:
- CTPS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 591
- Sequence:
- MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDAIQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHVSLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQVICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCSIALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQKLCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDANSTEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRHRFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPYFGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD
- Proteomes:
- UP000005640
Function
- Function:
- This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
- Pathway:
- Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.
- Catalytic Activity:
- ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.
- Enzyme Regulation:
- ENZYME REGULATION: Activated by GTP and inhibited by CTP.
- Active Site:
- ACT_SITE 399 399 For GATase activity.
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cytosol
membrane
ATP binding
CTP synthase activity
'de novo' CTP biosynthetic process
B cell proliferation
CTP biosynthetic process
glutamine metabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
response to drug
small molecule metabolic process
T cell proliferation - Gene Ontology Biological Process:
- 'de novo' CTP biosynthetic process
B cell proliferation
CTP biosynthetic process
glutamine metabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
response to drug
small molecule metabolic process
T cell proliferation - Gene Ontology Molecular Function:
- ATP binding
CTP synthase activity - Gene Ontology Cellular Component:
- cytosol
membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Glutamine amidotransferase
Immunity
Ligase
Nucleotide-binding
Phosphoprotein
Polymorphism
Pyrimidine biosynthesis
Reference proteome