Names & Taxonomy

Uniprot ID:
P17787
Entry Name:
ACHB2_HUMAN
Status:
reviewed
Protein Names:
Neuronal acetylcholine receptor subunit beta-2
Gene Names:
CHRNB2
Gene Names Primary:
CHRNB2
Organism:
Homo sapiens (Human)

Structure

Length:
502
Sequence:
MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Function

Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
Cross Reference Drug Bank:
DB00514 DB00898 DB00674 DB00184
Gene Ontology Go:
acetylcholine-gated channel complex
cell junction
external side of plasma membrane
integral component of membrane
plasma membrane
postsynaptic membrane
acetylcholine binding
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
drug binding
ligand-gated ion channel activity
action potential
associative learning
B cell activation
behavioral response to nicotine
calcium ion transport
central nervous system projection neuron axonogenesis
chemical synaptic transmission, postsynaptic
cognition
conditioned taste aversion
ion transport
lateral geniculate nucleus development
learning
locomotory behavior
membrane depolarization
memory
negative regulation of action potential
neurological system process
neuromuscular synaptic transmission
optic nerve morphogenesis
positive regulation of B cell proliferation
positive regulation of dopamine secretion
positive regulation of synaptic transmission, dopaminergic
protein heterooligomerization
regulation of circadian sleep/wake cycle, non-REM sleep
regulation of circadian sleep/wake cycle, REM sleep
regulation of dendrite morphogenesis
regulation of dopamine metabolic process
regulation of dopamine secretion
regulation of synapse assembly
regulation of synaptic transmission, dopaminergic
response to cocaine
response to ethanol
response to hypoxia
response to nicotine
sensory perception of pain
sensory perception of sound
signal transduction
smooth muscle contraction
social behavior
synaptic transmission
synaptic transmission involved in micturition
synaptic transmission, cholinergic
vestibulocochlear nerve development
visual learning
visual perception
Gene Ontology Biological Process:
action potential
associative learning
B cell activation
behavioral response to nicotine
calcium ion transport
central nervous system projection neuron axonogenesis
chemical synaptic transmission, postsynaptic
cognition
conditioned taste aversion
ion transport
lateral geniculate nucleus development
learning
locomotory behavior
membrane depolarization
memory
negative regulation of action potential
neurological system process
neuromuscular synaptic transmission
optic nerve morphogenesis
positive regulation of B cell proliferation
positive regulation of dopamine secretion
positive regulation of synaptic transmission, dopaminergic
protein heterooligomerization
regulation of circadian sleep/wake cycle, non-REM sleep
regulation of circadian sleep/wake cycle, REM sleep
regulation of dendrite morphogenesis
regulation of dopamine metabolic process
regulation of dopamine secretion
regulation of synapse assembly
regulation of synaptic transmission, dopaminergic
response to cocaine
response to ethanol
response to hypoxia
response to nicotine
sensory perception of pain
sensory perception of sound
signal transduction
smooth muscle contraction
social behavior
synaptic transmission
synaptic transmission, cholinergic
synaptic transmission involved in micturition
vestibulocochlear nerve development
visual learning
visual perception
Gene Ontology Molecular Function:
acetylcholine-activated cation-selective channel activity
acetylcholine binding
acetylcholine receptor activity
drug binding
ligand-gated ion channel activity
Gene Ontology Cellular Component:
acetylcholine-gated channel complex
cell junction
external side of plasma membrane
integral component of membrane
plasma membrane
postsynaptic membrane
Keywords:
3D-structure
Cell junction
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Epilepsy
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport
Interacts With:
P30532

Publication

PubMed ID:
2377478 8906617 9009220 9921897 10441742 15489334 16120769 20441771 22361591 11062464 11104662 11906688