Names & Taxonomy
- Uniprot ID:
- P17735
- Entry Name:
- ATTY_HUMAN
- Status:
- reviewed
- Protein Names:
- Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase)
- Gene Names:
- TAT
- Gene Names Primary:
- TAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 454
- Sequence:
- MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK
- Proteomes:
- UP000005640
Function
- Function:
- Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
- Pathway:
- Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.
- Catalytic Activity:
- L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00120 DB00135
- Gene Ontology Go:
- cytosol
mitochondrion
amino acid binding
L-phenylalanine:2-oxoglutarate aminotransferase activity
L-tyrosine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding
2-oxoglutarate metabolic process
biosynthetic process
cellular nitrogen compound metabolic process
glutamate metabolic process
L-phenylalanine catabolic process
response to glucocorticoid
response to mercury ion
response to oxidative stress
small molecule metabolic process
tyrosine catabolic process - Gene Ontology Biological Process:
- 2-oxoglutarate metabolic process
biosynthetic process
cellular nitrogen compound metabolic process
glutamate metabolic process
L-phenylalanine catabolic process
response to glucocorticoid
response to mercury ion
response to oxidative stress
small molecule metabolic process
tyrosine catabolic process - Gene Ontology Molecular Function:
- amino acid binding
L-phenylalanine:2-oxoglutarate aminotransferase activity
L-tyrosine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding - Gene Ontology Cellular Component:
- cytosol
mitochondrion - Keywords:
- 3D-structure
Acetylation
Aminotransferase
Complete proteome
Disease mutation
Mental retardation
Palmoplantar keratoderma
Phenylalanine catabolism
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase
Tyrosine catabolism