Names & Taxonomy

Uniprot ID:
P17735
Entry Name:
ATTY_HUMAN
Status:
reviewed
Protein Names:
Tyrosine aminotransferase (TAT) (EC 2.6.1.5) (L-tyrosine:2-oxoglutarate aminotransferase)
Gene Names:
TAT
Gene Names Primary:
TAT
Organism:
Homo sapiens (Human)

Structure

Length:
454
Sequence:
MDPYMIQMSSKGNLPSILDVHVNVGGRSSVPGKMKGRKARWSVRPSDMAKKTFNPIRAIVDNMKVKPNPNKTMISLSIGDPTVFGNLPTDPEVTQAMKDALDSGKYNGYAPSIGFLSSREEIASYYHCPEAPLEAKDVILTSGCSQAIDLCLAVLANPGQNILVPRPGFSLYKTLAESMGIEVKLYNLLPEKSWEIDLKQLEYLIDEKTACLIVNNPSNPCGSVFSKRHLQKILAVAARQCVPILADEIYGDMVFSDCKYEPLATLSTDVPILSCGGLAKRWLVPGWRLGWILIHDRRDIFGNEIRDGLVKLSQRILGPCTIVQGALKSILCRTPGEFYHNTLSFLKSNADLCYGALAAIPGLRPVRPSGAMYLMVGIEMEHFPEFENDVEFTERLVAEQSVHCLPATCFEYPNFIRVVITVPEVMMLEACSRIQEFCEQHYHCAEGSQEECDK
Proteomes:
UP000005640

Function

Function:
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Pathway:
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.
Catalytic Activity:
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
Cofactor:
COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Cross Reference Drug Bank:
DB00120 DB00135
Gene Ontology Go:
cytosol
mitochondrion
amino acid binding
L-phenylalanine:2-oxoglutarate aminotransferase activity
L-tyrosine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding
2-oxoglutarate metabolic process
biosynthetic process
cellular nitrogen compound metabolic process
glutamate metabolic process
L-phenylalanine catabolic process
response to glucocorticoid
response to mercury ion
response to oxidative stress
small molecule metabolic process
tyrosine catabolic process
Gene Ontology Biological Process:
2-oxoglutarate metabolic process
biosynthetic process
cellular nitrogen compound metabolic process
glutamate metabolic process
L-phenylalanine catabolic process
response to glucocorticoid
response to mercury ion
response to oxidative stress
small molecule metabolic process
tyrosine catabolic process
Gene Ontology Molecular Function:
amino acid binding
L-phenylalanine:2-oxoglutarate aminotransferase activity
L-tyrosine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding
Gene Ontology Cellular Component:
cytosol
mitochondrion
Keywords:
3D-structure
Acetylation
Aminotransferase
Complete proteome
Disease mutation
Mental retardation
Palmoplantar keratoderma
Phenylalanine catabolism
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase
Tyrosine catabolism

Publication

PubMed ID:
1973834 7908801 7999802 14702039 16640556 24275569 1357662