Names & Taxonomy
- Uniprot ID:
- P17658
- Entry Name:
- KCNA6_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel HBK2) (Voltage-gated potassium channel subunit Kv1.6)
- Gene Names:
- KCNA6
- Gene Names Primary:
- KCNA6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 529
- Sequence:
- MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITPGEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 410 421 Helical; Name=Pore helix.
Function
- Function:
- Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).
- Cross Reference Drug Bank:
- DB06637
- Gene Ontology Go:
- axon terminus
integral component of plasma membrane
plasma membrane
potassium channel complex
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
voltage-gated potassium channel activity
potassium ion transmembrane transport
potassium ion transport
protein homooligomerization
synaptic transmission - Gene Ontology Biological Process:
- potassium ion transmembrane transport
potassium ion transport
protein homooligomerization
synaptic transmission - Gene Ontology Molecular Function:
- delayed rectifier potassium channel activity
voltage-gated potassium channel activity - Gene Ontology Cellular Component:
- axon terminus
integral component of plasma membrane
plasma membrane
potassium channel complex
voltage-gated potassium channel complex - Keywords:
- Cell membrane
Complete proteome
Ion channel
Ion transport
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel