Names & Taxonomy
- Uniprot ID:
- P17544
- Entry Name:
- ATF7_HUMAN
- Status:
- reviewed
- Protein Names:
- Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A)
- Gene Names:
- ATF7 ATFA
- Gene Names Primary:
- ATF7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 494
- Sequence:
- MGDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKNCEEVGLFNELASSFEHEFKKAADEDEKKARSRTVAKKLVAAAGPLDMSLPSTPDIKIKEEEPVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTPTIVRPGSLPLHLGYDPLHPTLPSPTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQMPSVISLARPVSMVPNIPGIPGPPVNSSGSISPSGHPIPSEAKMRLKATLTHQVSSINGGCGMVVGTASTMVTARPEQSQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNRAAASRCRQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAHKDCPVTALQKKTQGYLESPKESSEPTGSPAPVIQHSSATAPSNGLSVRSAAEAVATSVLTQMASQRTELSMPIQSHVIMTPQSQSAGR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.; Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.; Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
- Cross Reference Drug Bank:
- DB00852
- Gene Ontology Go:
- cytoplasm
nuclear periphery
nucleoplasm
nucleus
enzyme binding
metal ion binding
mitogen-activated protein kinase binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
transcription, DNA-templated
viral process - Gene Ontology Biological Process:
- negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
transcription, DNA-templated
viral process - Gene Ontology Molecular Function:
- enzyme binding
metal ion binding
mitogen-activated protein kinase binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding - Gene Ontology Cellular Component:
- cytoplasm
nuclear periphery
nucleoplasm
nucleus - Keywords:
- Activator
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Host-virus interaction
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
Zinc
Zinc-finger - Interacts With:
- P18847; Q8N6L0; Q8IZU0; P06734; P01100; P15408; P0C746; P05412; P17275; P17535; Q9DGW5; Q9NX40; Q8WW34