Names & Taxonomy

Uniprot ID:
P17538
Entry Name:
CTRB1_HUMAN
Status:
reviewed
Protein Names:
Chymotrypsinogen B (EC 3.4.21.1) [Cleaved into: Chymotrypsin B chain A; Chymotrypsin B chain B; Chymotrypsin B chain C]
Gene Names:
CTRB1 CTRB
Gene Names Primary:
CTRB1
Organism:
Homo sapiens (Human)

Structure

Length:
263
Sequence:
MAFLWLLSCWALLGTTFGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQKILAAN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space.

Function

Catalytic Activity:
Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.
Active Site:
ACT_SITE 75 75 Charge relay system.
Cross Reference Drug Bank:
DB06692
Gene Ontology Go:
extracellular region
extracellular space
serine-type endopeptidase activity
cobalamin metabolic process
digestion
extracellular matrix disassembly
extracellular matrix organization
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Biological Process:
cobalamin metabolic process
digestion
extracellular matrix disassembly
extracellular matrix organization
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Ontology Molecular Function:
serine-type endopeptidase activity
Gene Ontology Cellular Component:
extracellular region
extracellular space
Keywords:
Complete proteome
Digestion
Disulfide bond
Hydrolase
Phosphoprotein
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Publication

PubMed ID:
2917002 15489334