Names & Taxonomy
- Uniprot ID:
- P16519
- Entry Name:
- NEC2_HUMAN
- Status:
- reviewed
- Protein Names:
- Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2)
- Gene Names:
- PCSK2 NEC2
- Gene Names Primary:
- PCSK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 638
- Sequence:
- MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
Function
- Function:
- Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
- Catalytic Activity:
- Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
- Active Site:
- ACT_SITE 167 167 Charge relay system.
- Cross Reference Drug Bank:
- DB00030
- Gene Ontology Go:
- dendrite
extracellular space
membrane
perikaryon
secretory granule lumen
transport vesicle
serine-type endopeptidase activity
cellular protein metabolic process
enkephalin processing
insulin processing
islet amyloid polypeptide processing
nervous system development
protein autoprocessing
proteolysis - Gene Ontology Biological Process:
- cellular protein metabolic process
enkephalin processing
insulin processing
islet amyloid polypeptide processing
nervous system development
protein autoprocessing
proteolysis - Gene Ontology Molecular Function:
- serine-type endopeptidase activity
- Gene Ontology Cellular Component:
- dendrite
extracellular space
membrane
perikaryon
secretory granule lumen
transport vesicle - Keywords:
- Alternative splicing
Cleavage on pair of basic residues
Complete proteome
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Hydrolase
Polymorphism
Protease
Reference proteome
Serine protease
Signal
Zymogen