Names & Taxonomy

Uniprot ID:
P16442
Entry Name:
BGAT_HUMAN
Status:
reviewed
Protein Names:
Histo-blood group ABO system transferase (Fucosylglycoprotein 3-alpha-galactosyltransferase) (Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase) (Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase) (EC 2.4.1.40) (Glycoprotein-fucosylgalactoside alpha-galactosyltransferase) (EC 2.4.1.37) (Histo-blood group A transferase) (A transferase) (Histo-blood group B transferase) (B transferase) (NAGAT) [Cleaved into: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form]
Gene Names:
ABO
Gene Names Primary:
ABO
Organism:
Homo sapiens (Human)

Structure

Length:
354
Sequence:
MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDHLQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.

Function

Function:
This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
Pathway:
Protein modification; protein glycosylation.
Catalytic Activity:
UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L-fucosyl-(1->2))-beta-D-galactose.
Cofactor:
COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Active Site:
ACT_SITE 303 303 Nucleophile.
Gene Ontology Go:
extracellular region
Golgi cisterna membrane
integral component of membrane
fucosylgalactoside 3-alpha-galactosyltransferase activity
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
metal ion binding
protein glycosylation
Gene Ontology Biological Process:
protein glycosylation
Gene Ontology Molecular Function:
fucosylgalactoside 3-alpha-galactosyltransferase activity
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
metal ion binding
Gene Ontology Cellular Component:
extracellular region
Golgi cisterna membrane
integral component of membrane
Keywords:
3D-structure
Blood group antigen
Complete proteome
Direct protein sequencing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Membrane
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal-anchor
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
2104828 2333095 7598760 16533287 17764507 18513251 15489334 12829588 8839869 9800297 15104652 1449469 2121736 10462501 12198488 12529355 12972418 15475562 16326711 17259183