Names & Taxonomy
- Uniprot ID:
- P16442
- Entry Name:
- BGAT_HUMAN
- Status:
- reviewed
- Protein Names:
- Histo-blood group ABO system transferase (Fucosylglycoprotein 3-alpha-galactosyltransferase) (Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase) (Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase) (EC 2.4.1.40) (Glycoprotein-fucosylgalactoside alpha-galactosyltransferase) (EC 2.4.1.37) (Histo-blood group A transferase) (A transferase) (Histo-blood group B transferase) (B transferase) (NAGAT) [Cleaved into: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form]
- Gene Names:
- ABO
- Gene Names Primary:
- ABO
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 354
- Sequence:
- MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDHLQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Function
- Function:
- This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
- Pathway:
- Protein modification; protein glycosylation.
- Catalytic Activity:
- UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L-fucosyl-(1->2))-beta-D-galactose.
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Active Site:
- ACT_SITE 303 303 Nucleophile.
- Gene Ontology Go:
- extracellular region
Golgi cisterna membrane
integral component of membrane
fucosylgalactoside 3-alpha-galactosyltransferase activity
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
metal ion binding
protein glycosylation - Gene Ontology Biological Process:
- protein glycosylation
- Gene Ontology Molecular Function:
- fucosylgalactoside 3-alpha-galactosyltransferase activity
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
metal ion binding - Gene Ontology Cellular Component:
- extracellular region
Golgi cisterna membrane
integral component of membrane - Keywords:
- 3D-structure
Blood group antigen
Complete proteome
Direct protein sequencing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Membrane
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal-anchor
Transferase
Transmembrane
Transmembrane helix