Names & Taxonomy
- Uniprot ID:
- P16435
- Entry Name:
- NCPR_HUMAN
- Status:
- reviewed
- Protein Names:
- NADPH--cytochrome P450 reductase (CPR) (P450R) (EC 1.6.2.4)
- Gene Names:
- POR CYPOR
- Gene Names Primary:
- POR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 677
- Sequence:
- MGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPAGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
- Catalytic Activity:
- NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Cross Reference Drug Bank:
- DB00865 DB00694 DB00997 DB01466 DB03147 DB00166 DB00305 DB00665 DB00698
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
mitochondrion
reductase activity
cytochrome-b5 reductase activity, acting on NAD(P)H
electron carrier activity
flavin adenine dinucleotide binding
FMN binding
hydrolase activity
iron ion binding
iron-cytochrome-c reductase activity
NADP binding
NADPH-hemoprotein reductase activity
nitric oxide dioxygenase activity
carnitine metabolic process
cellular organofluorine metabolic process
cellular response to follicle-stimulating hormone stimulus
cellular response to peptide hormone stimulus
demethylation
fatty acid oxidation
flavonoid metabolic process
internal peptidyl-lysine acetylation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of lipase activity
nitrate catabolic process
nitric oxide catabolic process
oxidation-reduction process
positive regulation of cholesterol biosynthetic process
positive regulation of chondrocyte differentiation
positive regulation of monooxygenase activity
positive regulation of smoothened signaling pathway
positive regulation of steroid hormone biosynthetic process
regulation of growth plate cartilage chondrocyte proliferation
response to drug
response to nutrient - Gene Ontology Biological Process:
- carnitine metabolic process
cellular organofluorine metabolic process
cellular response to follicle-stimulating hormone stimulus
cellular response to peptide hormone stimulus
demethylation
fatty acid oxidation
flavonoid metabolic process
internal peptidyl-lysine acetylation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of lipase activity
nitrate catabolic process
nitric oxide catabolic process
oxidation-reduction process
positive regulation of cholesterol biosynthetic process
positive regulation of chondrocyte differentiation
positive regulation of monooxygenase activity
positive regulation of smoothened signaling pathway
positive regulation of steroid hormone biosynthetic process
regulation of growth plate cartilage chondrocyte proliferation
response to drug
response to nutrient - Gene Ontology Molecular Function:
- reductase activity
cytochrome-b5 reductase activity, acting on NAD(P)H
electron carrier activity
flavin adenine dinucleotide binding
FMN binding
hydrolase activity
iron-cytochrome-c reductase activity
iron ion binding
NADP binding
NADPH-hemoprotein reductase activity
nitric oxide dioxygenase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
mitochondrion - Keywords:
- 3D-structure
Acetylation
Complete proteome
Congenital adrenal hyperplasia
Craniosynostosis
Direct protein sequencing
Disease mutation
Endoplasmic reticulum
FAD
FMN
Flavoprotein
Membrane
NADP
Oxidoreductase
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix - Interacts With:
- P00181; O00264