Names & Taxonomy
- Uniprot ID:
- P16219
- Entry Name:
- ACADS_HUMAN
- Status:
- reviewed
- Protein Names:
- Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)
- Gene Names:
- ACADS
- Gene Names Primary:
- ACADS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 412
- Sequence:
- MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix.
Function
- Function:
- Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms.
- Pathway:
- Lipid metabolism; mitochondrial fatty acid beta-oxidation.
- Catalytic Activity:
- A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Active Site:
- ACT_SITE 392 392 Proton acceptor.
- Cross Reference Drug Bank:
- DB03147
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
nucleus
acyl-CoA dehydrogenase activity
butyryl-CoA dehydrogenase activity
electron carrier activity
fatty-acyl-CoA binding
flavin adenine dinucleotide binding
butyrate catabolic process
cellular lipid metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA dehydrogenase
lipid homeostasis
protein homotetramerization
response to glucocorticoid
response to starvation
small molecule metabolic process - Gene Ontology Biological Process:
- butyrate catabolic process
cellular lipid metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA dehydrogenase
lipid homeostasis
protein homotetramerization
response to glucocorticoid
response to starvation
small molecule metabolic process - Gene Ontology Molecular Function:
- acyl-CoA dehydrogenase activity
butyryl-CoA dehydrogenase activity
electron carrier activity
fatty-acyl-CoA binding
flavin adenine dinucleotide binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion
nucleus - Keywords:
- 3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Disease mutation
FAD
Fatty acid metabolism
Flavoprotein
Lipid metabolism
Mitochondrion
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide