Names & Taxonomy

Uniprot ID:
P16219
Entry Name:
ACADS_HUMAN
Status:
reviewed
Protein Names:
Short-chain specific acyl-CoA dehydrogenase, mitochondrial (SCAD) (EC 1.3.8.1) (Butyryl-CoA dehydrogenase)
Gene Names:
ACADS
Gene Names Primary:
ACADS
Organism:
Homo sapiens (Human)

Structure

Length:
412
Sequence:
MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion matrix.

Function

Function:
Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms.
Pathway:
Lipid metabolism; mitochondrial fatty acid beta-oxidation.
Catalytic Activity:
A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
Cofactor:
COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
Active Site:
ACT_SITE 392 392 Proton acceptor.
Cross Reference Drug Bank:
DB03147
Gene Ontology Go:
mitochondrial matrix
mitochondrion
nucleus
acyl-CoA dehydrogenase activity
butyryl-CoA dehydrogenase activity
electron carrier activity
fatty-acyl-CoA binding
flavin adenine dinucleotide binding
butyrate catabolic process
cellular lipid metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA dehydrogenase
lipid homeostasis
protein homotetramerization
response to glucocorticoid
response to starvation
small molecule metabolic process
Gene Ontology Biological Process:
butyrate catabolic process
cellular lipid metabolic process
fatty acid beta-oxidation
fatty acid beta-oxidation using acyl-CoA dehydrogenase
lipid homeostasis
protein homotetramerization
response to glucocorticoid
response to starvation
small molecule metabolic process
Gene Ontology Molecular Function:
acyl-CoA dehydrogenase activity
butyryl-CoA dehydrogenase activity
electron carrier activity
fatty-acyl-CoA binding
flavin adenine dinucleotide binding
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
nucleus
Keywords:
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Disease mutation
FAD
Fatty acid metabolism
Flavoprotein
Lipid metabolism
Mitochondrion
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transit peptide

Publication

PubMed ID:
2565344 9383286 15489334 1286669 21269460 24275569 25944712 1692038 9499414 11134486