Names & Taxonomy
- Uniprot ID:
- P16118
- Entry Name:
- F261_HUMAN
- Status:
- reviewed
- Protein Names:
- 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
- Gene Names:
- PFKFB1 F6PK PFRX
- Gene Names Primary:
- PFKFB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 471
- Sequence:
- MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
- Proteomes:
- UP000005640
Function
- Function:
- Synthesis and degradation of fructose 2,6-bisphosphate.
- Catalytic Activity:
- Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.; ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Phosphorylation at Ser-33 inhibits the kinase and activates the bisphosphatase.
- Active Site:
- ACT_SITE 131 131
- Gene Ontology Go:
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
cytosol
6-phosphofructo-2-kinase activity
ATP binding
fructose-2,6-bisphosphate 2-phosphatase activity
fructose-6-phosphate binding
identical protein binding
canonical glycolysis
carbohydrate metabolic process
energy reserve metabolic process
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
gluconeogenesis
glucose metabolic process
glycolytic process
intracellular signal transduction
organ regeneration
positive regulation of glucokinase activity
response to cAMP
response to glucagon
response to glucocorticoid
response to insulin
response to starvation
small molecule metabolic process - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
energy reserve metabolic process
fructose 2,6-bisphosphate metabolic process
fructose metabolic process
gluconeogenesis
glucose metabolic process
glycolytic process
intracellular signal transduction
organ regeneration
positive regulation of glucokinase activity
response to cAMP
response to glucagon
response to glucocorticoid
response to insulin
response to starvation
small molecule metabolic process - Gene Ontology Molecular Function:
- 6-phosphofructo-2-kinase activity
ATP binding
fructose-2,6-bisphosphate 2-phosphatase activity
fructose-6-phosphate binding
identical protein binding - Gene Ontology Cellular Component:
- 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
cytosol - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Hydrolase
Kinase
Multifunctional enzyme
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase - Interacts With:
- Itself; P35557