Names & Taxonomy
- Uniprot ID:
- P16066
- Entry Name:
- ANPRA_HUMAN
- Status:
- reviewed
- Protein Names:
- Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)
- Gene Names:
- NPR1 ANPRA
- Gene Names Primary:
- NPR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1061
- Sequence:
- MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
- Catalytic Activity:
- GTP = 3',5'-cyclic GMP + diphosphate.
- Cross Reference Drug Bank:
- DB01612 DB01613 DB00883 DB04899 DB00727 DB00325
- Gene Ontology Go:
- guanylate cyclase complex, soluble
integral component of plasma membrane
plasma membrane
receptor complex
ATP binding
G-protein coupled peptide receptor activity
GTP binding
guanylate cyclase activity
hormone binding
natriuretic peptide receptor activity
peptide hormone binding
protein kinase activity
body fluid secretion
cardiac conduction
cell surface receptor signaling pathway
cGMP biosynthetic process
dopamine metabolic process
G-protein coupled receptor signaling pathway
intracellular signal transduction
negative regulation of angiogenesis
negative regulation of cell growth
negative regulation of smooth muscle cell proliferation
positive regulation of cGMP biosynthetic process
positive regulation of renal sodium excretion
positive regulation of urine volume
receptor guanylyl cyclase signaling pathway
regulation of blood pressure
regulation of cardiac conduction
regulation of vascular permeability
regulation of vasodilation - Gene Ontology Biological Process:
- body fluid secretion
cardiac conduction
cell surface receptor signaling pathway
cGMP biosynthetic process
dopamine metabolic process
G-protein coupled receptor signaling pathway
intracellular signal transduction
negative regulation of angiogenesis
negative regulation of cell growth
negative regulation of smooth muscle cell proliferation
positive regulation of cGMP biosynthetic process
positive regulation of renal sodium excretion
positive regulation of urine volume
receptor guanylyl cyclase signaling pathway
regulation of blood pressure
regulation of cardiac conduction
regulation of vascular permeability
regulation of vasodilation - Gene Ontology Molecular Function:
- ATP binding
G-protein coupled peptide receptor activity
GTP binding
guanylate cyclase activity
hormone binding
natriuretic peptide receptor activity
peptide hormone binding
protein kinase activity - Gene Ontology Cellular Component:
- guanylate cyclase complex, soluble
integral component of plasma membrane
plasma membrane
receptor complex - Keywords:
- Chloride
Complete proteome
Disulfide bond
GTP-binding
Glycoprotein
Lyase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Vasoactive
cGMP biosynthesis