Names & Taxonomy
- Uniprot ID:
- P15813
- Entry Name:
- CD1D_HUMAN
- Status:
- reviewed
- Protein Names:
- Antigen-presenting glycoprotein CD1d (R3G1) (CD antigen CD1d)
- Gene Names:
- CD1D
- Gene Names Primary:
- CD1D
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 335
- Sequence:
- MGCLLFLLLWALLQAWGSAEVPQRLFPLRCLQISSFANSSWTRTDGLAWLGELQTHSWSNDSDTVRSLKPWSQGTFSDQQWETLQHIFRVYRSSFTRDVKEFAKMLRLSYPLELQVSAGCEVHPGNASNNFFHVAFQGKDILSFQGTSWEPTQEAPLWVNLAIQVLNQDKWTRETVQWLLNGTCPQFVSGLLESGKSELKKQVKPKAWLSRGPSPGPGRLLLVCHVSGFYPKPVWVKWMRGEQEQQGTQPGDILPNADETWYLRATLDVVAGEAAGLSCRVKHSSLEGQDIVLYWGGSYTSMGLIALAVLACLLFLLIVGFTSRFKRQTSYQGVL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.
- Gene Ontology Go:
- basolateral plasma membrane
cell surface
cytoplasm
endoplasmic reticulum membrane
endosome membrane
integral component of plasma membrane
lysosomal membrane
beta-2-microglobulin binding
cell adhesion molecule binding
endogenous lipid antigen binding
exogenous lipid antigen binding
histone binding
lipid antigen binding
lipopeptide binding
receptor activity
antigen processing and presentation, endogenous lipid antigen via MHC class Ib
antigen processing and presentation, exogenous lipid antigen via MHC class Ib
detection of bacterium
heterotypic cell-cell adhesion
innate immune response
positive regulation of innate immune response
positive regulation of T cell proliferation
T cell selection
viral process - Gene Ontology Biological Process:
- antigen processing and presentation, endogenous lipid antigen via MHC class Ib
antigen processing and presentation, exogenous lipid antigen via MHC class Ib
detection of bacterium
heterotypic cell-cell adhesion
innate immune response
positive regulation of innate immune response
positive regulation of T cell proliferation
T cell selection
viral process - Gene Ontology Molecular Function:
- beta-2-microglobulin binding
cell adhesion molecule binding
endogenous lipid antigen binding
exogenous lipid antigen binding
histone binding
lipid antigen binding
lipopeptide binding
receptor activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
cell surface
cytoplasm
endoplasmic reticulum membrane
endosome membrane
integral component of plasma membrane
lysosomal membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Host-virus interaction
Immunity
Immunoglobulin domain
Innate immunity
Lysosome
Membrane
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix