Names & Taxonomy
- Uniprot ID:
- P15586
- Entry Name:
- GNS_HUMAN
- Status:
- reviewed
- Protein Names:
- N-acetylglucosamine-6-sulfatase (EC 3.1.6.14) (Glucosamine-6-sulfatase) (G6S)
- Gene Names:
- GNS
- Gene Names Primary:
- GNS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 552
- Sequence:
- MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRGSVRTRRFSKHLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Catalytic Activity:
- Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Gene Ontology Go:
- extracellular exosome
lysosomal lumen
metal ion binding
N-acetylglucosamine-6-sulfatase activity
sulfuric ester hydrolase activity
carbohydrate metabolic process
glycosaminoglycan catabolic process
glycosaminoglycan metabolic process
keratan sulfate catabolic process
keratan sulfate metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
glycosaminoglycan catabolic process
glycosaminoglycan metabolic process
keratan sulfate catabolic process
keratan sulfate metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- metal ion binding
N-acetylglucosamine-6-sulfatase activity
sulfuric ester hydrolase activity - Gene Ontology Cellular Component:
- extracellular exosome
lysosomal lumen - Keywords:
- Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Glycoprotein
Hydrolase
Lysosome
Metal-binding
Mucopolysaccharidosis
Polymorphism
Reference proteome
Signal - Interacts With:
- P16333