Names & Taxonomy
- Uniprot ID:
- P15509
- Entry Name:
- CSF2R_HUMAN
- Status:
- reviewed
- Protein Names:
- Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha) (GMCSFR-alpha) (GMR-alpha) (CDw116) (CD antigen CD116)
- Gene Names:
- CSF2RA CSF2R CSF2RY
- Gene Names Primary:
- CSF2RA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 400
- Sequence:
- MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Single-pass type I membrane protein.; Isoform 3: Secreted
Function
- Function:
- Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
- Cross Reference Drug Bank:
- DB00020
- Gene Ontology Go:
- extracellular region
integral component of plasma membrane
intracellular
plasma membrane
granulocyte colony-stimulating factor receptor activity
receptor activity
activation of MAPKK activity
axon guidance
cellular protein metabolic process
cellular response to granulocyte macrophage colony-stimulating factor stimulus
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
cellular protein metabolic process
cellular response to granulocyte macrophage colony-stimulating factor stimulus
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- granulocyte colony-stimulating factor receptor activity
receptor activity - Gene Ontology Cellular Component:
- extracellular region
integral component of plasma membrane
intracellular
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Receptor
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q969F0