Names & Taxonomy
- Uniprot ID:
- P15391
- Entry Name:
- CD19_HUMAN
- Status:
- reviewed
- Protein Names:
- B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)
- Gene Names:
- CD19
- Gene Names Primary:
- CD19
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 556
- Sequence:
- MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
- Cross Reference Drug Bank:
- DB09052
- Gene Ontology Go:
- external side of plasma membrane
extracellular exosome
integral component of plasma membrane
intracellular
plasma membrane
protein complex
receptor signaling protein activity
B cell receptor signaling pathway
cell surface receptor signaling pathway
cellular defense response
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
regulation of immune response - Gene Ontology Biological Process:
- B cell receptor signaling pathway
cell surface receptor signaling pathway
cellular defense response
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
regulation of immune response - Gene Ontology Molecular Function:
- receptor signaling protein activity
- Gene Ontology Cellular Component:
- external side of plasma membrane
extracellular exosome
integral component of plasma membrane
intracellular
plasma membrane
protein complex - Keywords:
- Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P01871