Names & Taxonomy

Uniprot ID:
P15382
Entry Name:
KCNE1_HUMAN
Status:
reviewed
Protein Names:
Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel)
Gene Names:
KCNE1
Gene Names Primary:
KCNE1
Organism:
Homo sapiens (Human)

Structure

Length:
129
Sequence:
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNTHLPETKPSP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Cross Reference Drug Bank:
DB00808
Gene Ontology Go:
apical plasma membrane
cell surface
lysosome
membrane raft
plasma membrane
voltage-gated potassium channel complex
Z disc
delayed rectifier potassium channel activity
potassium channel regulator activity
telethonin binding
cardiac conduction
cardiac muscle cell action potential involved in contraction
cellular response to cAMP
membrane repolarization
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
negative regulation of delayed rectifier potassium channel activity
negative regulation of protein targeting to membrane
positive regulation of potassium ion transmembrane transport
potassium ion export
potassium ion transmembrane transport
protein N-linked glycosylation
protein O-linked glycosylation
regulation of delayed rectifier potassium channel activity
regulation of heart rate by cardiac conduction
regulation of potassium ion transmembrane transport
regulation of ventricular cardiac muscle cell membrane repolarization
sensory perception of sound
ventricular cardiac muscle cell action potential
Gene Ontology Biological Process:
cardiac conduction
cardiac muscle cell action potential involved in contraction
cellular response to cAMP
membrane repolarization
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
negative regulation of delayed rectifier potassium channel activity
negative regulation of protein targeting to membrane
positive regulation of potassium ion transmembrane transport
potassium ion export
potassium ion transmembrane transport
protein N-linked glycosylation
protein O-linked glycosylation
regulation of delayed rectifier potassium channel activity
regulation of heart rate by cardiac conduction
regulation of potassium ion transmembrane transport
regulation of ventricular cardiac muscle cell membrane repolarization
sensory perception of sound
ventricular cardiac muscle cell action potential
Gene Ontology Molecular Function:
delayed rectifier potassium channel activity
potassium channel regulator activity
telethonin binding
Gene Ontology Cellular Component:
apical plasma membrane
cell surface
lysosome
membrane raft
plasma membrane
voltage-gated potassium channel complex
Z disc
Keywords:
3D-structure
Cell membrane
Complete proteome
Deafness
Disease mutation
Glycoprotein
Ion channel
Ion transport
Long QT syndrome
Membrane
Phosphoprotein
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel
Interacts With:
P51787; A6HIS0

Publication

PubMed ID:
2730656 7828904 15489334 9312006 9230439 11874988 19219384 20533308 21676880 21669976 18611041 8899564 9328483 9354783 9354802 9445165 10400998 10973849 11692163 15051636 16414944 16823764 19716085 25037568