Names & Taxonomy
- Uniprot ID:
- P15336
- Entry Name:
- ATF2_HUMAN
- Status:
- reviewed
- Protein Names:
- Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (EC 2.3.1.48) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (Histone acetyltransferase ATF2) (cAMP response element-binding protein CRE-BP1)
- Gene Names:
- ATF2 CREB2 CREBP1
- Gene Names Primary:
- ATF2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 505
- Sequence:
- MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMAPSSQSQPSGS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm. Mitochondrion outer membrane. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
Function
- Function:
- Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
- Catalytic Activity:
- Acetyl-CoA + = CoA + acetyl-.
- Cross Reference Drug Bank:
- DB00852
- Gene Ontology Go:
- cytoplasm
mitochondrial outer membrane
nucleoplasm
nucleus
site of double-strand break
cAMP response element binding
cAMP response element binding protein binding
chromatin binding
enhancer sequence-specific DNA binding
histone acetyltransferase activity
metal ion binding
protein kinase binding
RNA polymerase II activating transcription factor binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcription coactivator activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
adipose tissue development
amelogenesis
cellular response to DNA damage stimulus
chromatin organization
fat cell differentiation
histone acetylation
innate immune response
intra-S DNA damage checkpoint
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
negative regulation of epithelial cell proliferation
negative regulation of transcription from RNA polymerase II promoter
outflow tract morphogenesis
positive regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of neuron apoptotic process
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transforming growth factor beta2 production
regulation of sequence-specific DNA binding transcription factor activity
regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
response to osmotic stress
response to water deprivation
stress-activated MAPK cascade
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway - Gene Ontology Biological Process:
- adipose tissue development
amelogenesis
cellular response to DNA damage stimulus
chromatin organization
fat cell differentiation
histone acetylation
innate immune response
intra-S DNA damage checkpoint
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
negative regulation of epithelial cell proliferation
negative regulation of transcription from RNA polymerase II promoter
outflow tract morphogenesis
positive regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of neuron apoptotic process
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transforming growth factor beta2 production
regulation of sequence-specific DNA binding transcription factor activity
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to osmotic stress
response to water deprivation
stress-activated MAPK cascade
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- cAMP response element binding
cAMP response element binding protein binding
chromatin binding
enhancer sequence-specific DNA binding
histone acetyltransferase activity
metal ion binding
protein kinase binding
RNA polymerase II activating transcription factor binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription coactivator activity
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor activity, RNA polymerase II transcription factor binding
transcription factor activity, sequence-specific DNA binding - Gene Ontology Cellular Component:
- cytoplasm
mitochondrial outer membrane
nucleoplasm
nucleus
site of double-strand break - Keywords:
- 3D-structure
Acetylation
Activator
Alternative splicing
Complete proteome
Cytoplasm
DNA damage
DNA-binding
Membrane
Metal-binding
Mitochondrion
Mitochondrion outer membrane
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription
Transcription regulation
Transferase
Zinc
Zinc-finger - Interacts With:
- P18847; Q99966; Q96B26; P01100; Q6FG41; P15408; P0C746; P56524; P05412; P17275; P17535; Q9BVG8; P45984; Q9DGW5; O95644; Q15532; P63165; A4PIW0; Q99986; Q8IUH5