Names & Taxonomy
- Uniprot ID:
- P15328
- Entry Name:
- FOLR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Folate receptor alpha (FR-alpha) (Adult folate-binding protein) (FBP) (Folate receptor 1) (Folate receptor, adult) (KB cells FBP) (Ovarian tumor-associated antigen MOv18)
- Gene Names:
- FOLR1 FOLR
- Gene Names Primary:
- FOLR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 257
- Sequence:
- MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Lipid-anchor, GPI-anchor. Secreted
Function
- Function:
- Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
- Cross Reference Drug Bank:
- DB00563
- Gene Ontology Go:
- anchored component of external side of plasma membrane
apical plasma membrane
basolateral plasma membrane
brush border membrane
cell surface
clathrin-coated vesicle
endoplasmic reticulum membrane
endoplasmic reticulum-Golgi intermediate compartment membrane
endosome
ER to Golgi transport vesicle membrane
extracellular exosome
Golgi membrane
integral component of plasma membrane
membrane
nucleus
plasma membrane
drug binding
folic acid binding
folic acid receptor activity
folic acid transporter activity
methotrexate binding
receptor activity
anterior neural tube closure
axon regeneration
cardiac neural crest cell migration involved in outflow tract morphogenesis
cellular protein metabolic process
cellular response to folic acid
COPII vesicle coating
ER to Golgi vesicle-mediated transport
folic acid metabolic process
folic acid transport
heart looping
membrane organization
neural crest cell migration involved in heart formation
pharyngeal arch artery morphogenesis
post-translational protein modification
protein N-linked glycosylation via asparagine
receptor-mediated endocytosis
regulation of canonical Wnt signaling pathway
regulation of transforming growth factor beta receptor signaling pathway - Gene Ontology Biological Process:
- anterior neural tube closure
axon regeneration
cardiac neural crest cell migration involved in outflow tract morphogenesis
cellular protein metabolic process
cellular response to folic acid
COPII vesicle coating
ER to Golgi vesicle-mediated transport
folic acid metabolic process
folic acid transport
heart looping
membrane organization
neural crest cell migration involved in heart formation
pharyngeal arch artery morphogenesis
post-translational protein modification
protein N-linked glycosylation via asparagine
receptor-mediated endocytosis
regulation of canonical Wnt signaling pathway
regulation of transforming growth factor beta receptor signaling pathway - Gene Ontology Molecular Function:
- drug binding
folic acid binding
folic acid receptor activity
folic acid transporter activity
methotrexate binding
receptor activity - Gene Ontology Cellular Component:
- anchored component of external side of plasma membrane
apical plasma membrane
basolateral plasma membrane
brush border membrane
cell surface
clathrin-coated vesicle
endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum membrane
endosome
ER to Golgi transport vesicle membrane
extracellular exosome
Golgi membrane
integral component of plasma membrane
membrane
nucleus
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Endosome
Folate-binding
GPI-anchor
Glycoprotein
Lipoprotein
Membrane
Neurodegeneration
Polymorphism
Receptor
Reference proteome
Secreted
Signal
Transport