Names & Taxonomy
- Uniprot ID:
- P15260
- Entry Name:
- INGR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (CD antigen CD119)
- Gene Names:
- IFNGR1
- Gene Names Primary:
- IFNGR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 489
- Sequence:
- MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNGSEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFNSSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEENIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLESHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYRPTEDSKEFS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114).
- Cross Reference Drug Bank:
- DB00033
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
interferon-gamma receptor activity
interleukin-20 binding
cytokine-mediated signaling pathway
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
response to virus
signal transduction - Gene Ontology Biological Process:
- cytokine-mediated signaling pathway
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
response to virus
signal transduction - Gene Ontology Molecular Function:
- interferon-gamma receptor activity
interleukin-20 binding - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P42224