Names & Taxonomy
- Uniprot ID:
- P15259
- Entry Name:
- PGAM2_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphoglycerate mutase 2 (EC 3.1.3.13) (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 2) (Muscle-specific phosphoglycerate mutase) (Phosphoglycerate mutase isozyme M) (PGAM-M)
- Gene Names:
- PGAM2 PGAMM
- Gene Names Primary:
- PGAM2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 253
- Sequence:
- MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVRKAMEAVAAQGKAK
- Proteomes:
- UP000005640
Function
- Function:
- Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
- Catalytic Activity:
- 2-phospho-D-glycerate = 3-phospho-D-glycerate.; 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.; 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.
- Active Site:
- ACT_SITE 11 11 Tele-phosphohistidine intermediate.
- Gene Ontology Go:
- cytosol
extracellular exosome
nucleus
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
bisphosphoglycerate 2-phosphatase activity
bisphosphoglycerate mutase activity
cofactor binding
phosphoglycerate mutase activity
canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
glycolytic process
Notch signaling pathway
regulation of pentose-phosphate shunt
response to mercury ion
small molecule metabolic process
spermatogenesis
striated muscle contraction - Gene Ontology Biological Process:
- canonical glycolysis
carbohydrate metabolic process
gluconeogenesis
glucose metabolic process
glycolytic process
Notch signaling pathway
regulation of pentose-phosphate shunt
response to mercury ion
small molecule metabolic process
spermatogenesis
striated muscle contraction - Gene Ontology Molecular Function:
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
bisphosphoglycerate 2-phosphatase activity
bisphosphoglycerate mutase activity
cofactor binding
phosphoglycerate mutase activity - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
nucleus - Keywords:
- Complete proteome
Disease mutation
Glycogen storage disease
Glycolysis
Hydrolase
Isomerase
Isopeptide bond
Phosphoprotein
Reference proteome
Ubl conjugation