Names & Taxonomy
- Uniprot ID:
- P15151
- Entry Name:
- PVR_HUMAN
- Status:
- reviewed
- Protein Names:
- Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)
- Gene Names:
- PVR PVS
- Gene Names Primary:
- PVR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 417
- Sequence:
- MARAMAAAWPLLLVALLVLSWPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGISRNAIIFLVLGILVFLILLGIGIYFYWSKCSREVLWHCHLCPSSTEHASASANGHVSYSAVSRENSSSQDPQTEGTR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform Alpha: Cell membrane; Single-pass type I membrane protein.; Isoform Delta: Cell membrane; Single-pass type I membrane protein.; Isoform Beta: Secreted.; Isoform Gamma: Secreted.
Function
- Function:
- Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=72 nM for VTN;
- Gene Ontology Go:
- cell surface
cell-cell adherens junction
cytoplasm
extracellular exosome
extracellular space
focal adhesion
integral component of membrane
integral component of plasma membrane
plasma membrane
cell adhesion molecule binding
protein homodimerization activity
receptor activity
receptor binding
virus receptor activity
adherens junction organization
cell junction assembly
cell recognition
cell-cell junction organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homophilic cell adhesion via plasma membrane adhesion molecules
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
regulation of immune response
susceptibility to natural killer cell mediated cytotoxicity
susceptibility to T cell mediated cytotoxicity - Gene Ontology Biological Process:
- adherens junction organization
cell-cell junction organization
cell junction assembly
cell recognition
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
homophilic cell adhesion via plasma membrane adhesion molecules
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
regulation of immune response
susceptibility to natural killer cell mediated cytotoxicity
susceptibility to T cell mediated cytotoxicity - Gene Ontology Molecular Function:
- cell adhesion molecule binding
protein homodimerization activity
receptor activity
receptor binding
virus receptor activity - Gene Ontology Cellular Component:
- cell-cell adherens junction
cell surface
cytoplasm
extracellular exosome
extracellular space
focal adhesion
integral component of membrane
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P60409; P60410; P60411; Q7Z3S9; Q9BRI3