Names & Taxonomy
- Uniprot ID:
- P15104
- Entry Name:
- GLNA_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate decarboxylase) (EC 4.1.1.15) (Glutamate--ammonia ligase)
- Gene Names:
- GLUL GLNS
- Gene Names Primary:
- GLUL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 373
- Sequence:
- MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Mitochondrion
Function
- Function:
- This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
- Catalytic Activity:
- ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.; L-glutamate = 4-aminobutanoate + CO(2).
- Cofactor:
- COFACTOR: Name=biotin; Xref=ChEBI:CHEBI:57586;
- Cross Reference Drug Bank:
- DB06774 DB01212 DB01119 DB00130 DB00134 DB00082
- Gene Ontology Go:
- axon terminus
cytoplasm
cytosol
extracellular exosome
glial cell projection
mitochondrion
myelin sheath
nucleus
perikaryon
protein complex
rough endoplasmic reticulum
ATP binding
glutamate binding
glutamate decarboxylase activity
glutamate-ammonia ligase activity
identical protein binding
magnesium ion binding
manganese ion binding
ammonia assimilation cycle
cell proliferation
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
cellular response to starvation
glutamate catabolic process
glutamine biosynthetic process
neurotransmitter uptake
positive regulation of epithelial cell proliferation
positive regulation of insulin secretion
positive regulation of synaptic transmission, glutamatergic
protein homooligomerization
response to glucose
small molecule metabolic process
synaptic transmission - Gene Ontology Biological Process:
- ammonia assimilation cycle
cell proliferation
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
cellular response to starvation
glutamate catabolic process
glutamine biosynthetic process
neurotransmitter uptake
positive regulation of epithelial cell proliferation
positive regulation of insulin secretion
positive regulation of synaptic transmission, glutamatergic
protein homooligomerization
response to glucose
small molecule metabolic process
synaptic transmission - Gene Ontology Molecular Function:
- ATP binding
glutamate-ammonia ligase activity
glutamate binding
glutamate decarboxylase activity
identical protein binding
magnesium ion binding
manganese ion binding - Gene Ontology Cellular Component:
- axon terminus
cytoplasm
cytosol
extracellular exosome
glial cell projection
mitochondrion
myelin sheath
nucleus
perikaryon
protein complex
rough endoplasmic reticulum - Keywords:
- 3D-structure
ATP-binding
Acetylation
Complete proteome
Cytoplasm
Disease mutation
Ligase
Lyase
Mitochondrion
Nucleotide-binding
Phosphoprotein
Reference proteome
Ubl conjugation - Interacts With:
- Itself; B4URF7