Names & Taxonomy
- Uniprot ID:
- P15090
- Entry Name:
- FABP4_HUMAN
- Status:
- reviewed
- Protein Names:
- Fatty acid-binding protein, adipocyte (Adipocyte lipid-binding protein) (ALBP) (Adipocyte-type fatty acid-binding protein) (A-FABP) (AFABP) (Fatty acid-binding protein 4)
- Gene Names:
- FABP4
- Gene Names Primary:
- FABP4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 132
- Sequence:
- MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity).
Function
- Function:
- Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
- Cross Reference Drug Bank:
- DB04224
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
lipid particle
nucleus
fatty acid binding
transporter activity
brown fat cell differentiation
cellular response to lithium ion
cholesterol homeostasis
cytokine production
negative regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of inflammatory response
small molecule metabolic process
triglyceride catabolic process
white fat cell differentiation - Gene Ontology Biological Process:
- brown fat cell differentiation
cellular response to lithium ion
cholesterol homeostasis
cytokine production
negative regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of inflammatory response
small molecule metabolic process
triglyceride catabolic process
white fat cell differentiation - Gene Ontology Molecular Function:
- fatty acid binding
transporter activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
lipid particle
nucleus - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Lipid-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transport