Names & Taxonomy

Uniprot ID:
P15088
Entry Name:
CBPA3_HUMAN
Status:
reviewed
Protein Names:
Mast cell carboxypeptidase A (MC-CPA) (EC 3.4.17.1) (Carboxypeptidase A3)
Gene Names:
CPA3
Gene Names Primary:
CPA3
Organism:
Homo sapiens (Human)

Structure

Length:
417
Sequence:
MRLILPVGLIATTLAIAPVRFDREKVFRVKPQDEKQADIIKDLAKTNELDFWYPGATHHVAANMMVDFRVSEKESQAIQSALDQNKMHYEILIHDLQEEIEKQFDVKEDIPGRHSYAKYNNWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIGEKNERRKAIFTDCGIHAREWVSPAFCQWFVYQATKTYGRNKIMTKLLDRMNFYILPVFNVDGYIWSWTKNRMWRKNRSKNQNSKCIGTDLNRNFNASWNSIPNTNDPCADNYRGSAPESEKETKAVTNFIRSHLNEIKVYITFHSYSQMLLFPYGYTSKLPPNHEDLAKVAKIGTDVLSTRYETRYIYGPIESTIYPISGSSLDWAYDLGIKHTFAFELRDKGKFGFLLPESRIKPTCRETMLAVKFIAKYILKHTS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle. Note=Secretory granules.

Function

Catalytic Activity:
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Active Site:
ACT_SITE 378 378 Proton donor/acceptor.
Gene Ontology Go:
extracellular region
extracellular space
secretory granule
transport vesicle
metallocarboxypeptidase activity
zinc ion binding
angiotensin maturation
cellular protein metabolic process
positive regulation of defense response to virus by host
proteolysis
xenophagy
Gene Ontology Biological Process:
angiotensin maturation
cellular protein metabolic process
positive regulation of defense response to virus by host
proteolysis
xenophagy
Gene Ontology Molecular Function:
metallocarboxypeptidase activity
zinc ion binding
Gene Ontology Cellular Component:
extracellular region
extracellular space
secretory granule
transport vesicle
Keywords:
Carboxypeptidase
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Signal
Zinc
Zymogen

Publication

PubMed ID:
2594780 1729276 16641997 15489334 1629626 2708524