Names & Taxonomy

Uniprot ID:
P15085
Entry Name:
CBPA1_HUMAN
Status:
reviewed
Protein Names:
Carboxypeptidase A1 (EC 3.4.17.1)
Gene Names:
CPA1 CPA
Gene Names Primary:
CPA1
Organism:
Homo sapiens (Human)

Structure

Length:
419
Sequence:
MRGLLVLSVLLGAVFGKEDFVGHQVLRISVADEAQVQKVKELEDLEHLQLDFWRGPAHPGSPIDVRVPFPSIQAVKIFLESHGISYETMIEDVQSLLDEEQEQMFAFRSRARSTDTFNYATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGSKRPAIWIDTGIHSREWVTQASGVWFAKKITQDYGQDAAFTAILDTLDIFLEIVTNPDGFAFTHSTNRMWRKTRSHTAGSLCIGVDPNRNWDAGFGLSGASSNPCSETYHGKFANSEVEVKSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYSQGIKYSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIMEHTLNHPY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Catalytic Activity:
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Active Site:
ACT_SITE 380 380 Proton donor/acceptor.
Gene Ontology Go:
extracellular space
metallocarboxypeptidase activity
zinc ion binding
proteolysis
Gene Ontology Biological Process:
proteolysis
Gene Ontology Molecular Function:
metallocarboxypeptidase activity
zinc ion binding
Gene Ontology Cellular Component:
extracellular space
Keywords:
3D-structure
Carboxypeptidase
Complete proteome
Direct protein sequencing
Disulfide bond
Hydrolase
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Secreted
Signal
Zinc
Zymogen

Publication

PubMed ID:
1417781 8806703 14702039 12690205 15489334 2307232 2920728 8318831 1969228 18566513 19179285