Names & Taxonomy
- Uniprot ID:
- P14868
- Entry Name:
- SYDC_HUMAN
- Status:
- reviewed
- Protein Names:
- Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein)
- Gene Names:
- DARS PIG40
- Gene Names Orf:
- PIG40
- Gene Names Primary:
- DARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 501
- Sequence:
- MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
- Catalytic Activity:
- ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
- Cross Reference Drug Bank:
- DB00128
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
membrane
aminoacylase activity
aspartate-tRNA ligase activity
ATP binding
poly(A) RNA binding
aspartyl-tRNA aminoacylation
cellular nitrogen compound metabolic process
gene expression
protein complex assembly
selenium compound metabolic process
small molecule metabolic process
translation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- aspartyl-tRNA aminoacylation
cellular nitrogen compound metabolic process
gene expression
protein complex assembly
selenium compound metabolic process
small molecule metabolic process
translation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- aminoacylase activity
aspartate-tRNA ligase activity
ATP binding
poly(A) RNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
membrane - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Complete proteome
Cytoplasm
Disease mutation
Ligase
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
Reference proteome - Interacts With:
- Q13155; Q08050; P62993