Names & Taxonomy
- Uniprot ID:
- P14784
- Entry Name:
- IL2RB_HUMAN
- Status:
- reviewed
- Protein Names:
- Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
- Gene Names:
- IL2RB
- Gene Names Primary:
- IL2RB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 551
- Sequence:
- MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
- Cross Reference Drug Bank:
- DB00041 DB00074 DB00111 DB00004
- Gene Ontology Go:
- external side of plasma membrane
integral component of plasma membrane
intracellular
membrane
plasma membrane
interleukin-2 binding
interleukin-2 receptor activity
activation of MAPKK activity
axon guidance
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
natural killer cell activation
negative regulation of apoptotic process
neurotrophin TRK receptor signaling pathway
protein complex assembly
Ras protein signal transduction
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
viral process - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
natural killer cell activation
negative regulation of apoptotic process
neurotrophin TRK receptor signaling pathway
protein complex assembly
Ras protein signal transduction
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
viral process - Gene Ontology Molecular Function:
- interleukin-2 binding
interleukin-2 receptor activity - Gene Ontology Cellular Component:
- external side of plasma membrane
integral component of plasma membrane
intracellular
membrane
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Disulfide bond
Glycoprotein
Host-virus interaction
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P40933