Names & Taxonomy

Uniprot ID:
P14784
Entry Name:
IL2RB_HUMAN
Status:
reviewed
Protein Names:
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene Names:
IL2RB
Gene Names Primary:
IL2RB
Organism:
Homo sapiens (Human)

Structure

Length:
551
Sequence:
MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
Cross Reference Drug Bank:
DB00041 DB00074 DB00111 DB00004
Gene Ontology Go:
external side of plasma membrane
integral component of plasma membrane
intracellular
membrane
plasma membrane
interleukin-2 binding
interleukin-2 receptor activity
activation of MAPKK activity
axon guidance
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
natural killer cell activation
negative regulation of apoptotic process
neurotrophin TRK receptor signaling pathway
protein complex assembly
Ras protein signal transduction
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
viral process
Gene Ontology Biological Process:
activation of MAPKK activity
axon guidance
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
MAPK cascade
natural killer cell activation
negative regulation of apoptotic process
neurotrophin TRK receptor signaling pathway
protein complex assembly
Ras protein signal transduction
signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway
viral process
Gene Ontology Molecular Function:
interleukin-2 binding
interleukin-2 receptor activity
Gene Ontology Cellular Component:
external side of plasma membrane
integral component of plasma membrane
intracellular
membrane
plasma membrane
Keywords:
3D-structure
Complete proteome
Disulfide bond
Glycoprotein
Host-virus interaction
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Interacts With:
P40933

Publication

PubMed ID:
2785715 15461802 14702039 10591208 15489334 8648694 12200137 7529123 16293754 16477002