Names & Taxonomy
- Uniprot ID:
- P14207
- Entry Name:
- FOLR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP)
- Gene Names:
- FOLR2
- Gene Names Primary:
- FOLR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 255
- Sequence:
- MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Lipid-anchor, GPI-anchor. Secreted
Function
- Function:
- Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
- Cross Reference Drug Bank:
- DB00158
- Gene Ontology Go:
- anchored component of external side of plasma membrane
cell surface
extracellular region
membrane
drug binding
folic acid binding
folic acid receptor activity
folic acid transporter activity
methotrexate binding
cellular response to folic acid
folic acid transport
inflammatory response
positive regulation of cell proliferation
receptor-mediated endocytosis
regulation of thymidylate synthase biosynthetic process - Gene Ontology Biological Process:
- cellular response to folic acid
folic acid transport
inflammatory response
positive regulation of cell proliferation
receptor-mediated endocytosis
regulation of thymidylate synthase biosynthetic process - Gene Ontology Molecular Function:
- drug binding
folic acid binding
folic acid receptor activity
folic acid transporter activity
methotrexate binding - Gene Ontology Cellular Component:
- anchored component of external side of plasma membrane
cell surface
extracellular region
membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Folate-binding
GPI-anchor
Glycoprotein
Lipoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Secreted
Signal
Transport