Names & Taxonomy
- Uniprot ID:
- P14061
- Entry Name:
- DHB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Placental 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 1)
- Gene Names:
- HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17 SDR28C1
- Gene Names Primary:
- HSD17B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 328
- Sequence:
- MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
- Pathway:
- Steroid biosynthesis; estrogen biosynthesis.
- Catalytic Activity:
- 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
- Active Site:
- ACT_SITE 156 156 Proton acceptor.
- Cross Reference Drug Bank:
- DB02187
- Gene Ontology Go:
- cytoplasm
cytosol
nuclear membrane
nucleoplasm
catalytic activity
estradiol 17-beta-dehydrogenase activity
testosterone dehydrogenase (NAD+) activity
bone development
cellular response to metal ion
estrogen biosynthetic process
estrogen metabolic process
small molecule metabolic process
steroid biosynthetic process
steroid metabolic process
testosterone biosynthetic process - Gene Ontology Biological Process:
- bone development
cellular response to metal ion
estrogen biosynthetic process
estrogen metabolic process
small molecule metabolic process
steroid biosynthetic process
steroid metabolic process
testosterone biosynthetic process - Gene Ontology Molecular Function:
- catalytic activity
estradiol 17-beta-dehydrogenase activity
testosterone dehydrogenase (NAD+) activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nuclear membrane
nucleoplasm - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Direct protein sequencing
Lipid biosynthesis
Lipid metabolism
NADP
Oxidoreductase
Polymorphism
Reference proteome
Steroid biosynthesis