Names & Taxonomy
- Uniprot ID:
- P13866
- Entry Name:
- SC5A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)
- Gene Names:
- SLC5A1 NAGT SGLT1
- Gene Names Primary:
- SLC5A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 664
- Sequence:
- MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 527 563 Helical.
Function
- Function:
- Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
- Cross Reference Drug Bank:
- DB08907
- Gene Ontology Go:
- apical plasma membrane
brush border membrane
cell-cell junction
extracellular exosome
integral component of plasma membrane
plasma membrane
glucose:sodium symporter activity
carbohydrate metabolic process
glucose transport
hexose transport
small molecule metabolic process
transmembrane transport - Gene Ontology Biological Process:
- carbohydrate metabolic process
glucose transport
hexose transport
small molecule metabolic process
transmembrane transport - Gene Ontology Molecular Function:
- glucose:sodium symporter activity
- Gene Ontology Cellular Component:
- apical plasma membrane
brush border membrane
cell-cell junction
extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Sugar transport
Symport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P00533