Names & Taxonomy
- Uniprot ID:
- P13796
- Entry Name:
- PLSL_HUMAN
- Status:
- reviewed
- Protein Names:
- Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)
- Gene Names:
- LCP1 PLS2
- Gene Names Primary:
- LCP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 627
- Sequence:
- MARGSVSDEEMMELREAFAKVDTDGNGYISFNELNDLFKAACLPLPGYRVREITENLMATGDLDQDGRISFDEFIKIFHGLKSTDVAKTFRKAINKKEGICAIGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTNDLFNAVGDGIVLCKMINLSVPDTIDERTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEELLLRWANYHLENAGCNKIGNFSTDIKDSKAYYHLLEQVAPKGDEEGVPAVVIDMSGLREKDDIQRAECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNRYPALHKPENQDIDWGALEGETREERTFRNWMNSLGVNPRVNHLYSDLSDALVIFQLYEKIKVPVDWNRVNKPPYPKLGGNMKKLENCNYAVELGKNQAKFSLVGIGGQDLNEGNRTLTLALIWQLMRRYTLNILEEIGGGQKVNDDIIVNWVNETLREAKKSSSISSFKDPKISTSLPVLDLIDAIQPGSINYDLLKTENLNDDEKLNNAKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLMGKGMKRV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
- Gene Ontology Go:
- actin cytoskeleton
actin filament
actin filament bundle
cytoplasm
cytosol
extracellular exosome
extracellular space
filopodium
focal adhesion
phagocytic cup
plasma membrane
podosome
ruffle
ruffle membrane
actin binding
actin filament binding
calcium ion binding
GTPase binding
actin filament bundle assembly
cell migration
extracellular matrix disassembly
organ regeneration
positive regulation of podosome assembly
protein kinase A signaling
regulation of intracellular protein transport
T cell activation involved in immune response - Gene Ontology Biological Process:
- actin filament bundle assembly
cell migration
extracellular matrix disassembly
organ regeneration
positive regulation of podosome assembly
protein kinase A signaling
regulation of intracellular protein transport
T cell activation involved in immune response - Gene Ontology Molecular Function:
- actin binding
actin filament binding
calcium ion binding
GTPase binding - Gene Ontology Cellular Component:
- actin cytoskeleton
actin filament
actin filament bundle
cytoplasm
cytosol
extracellular exosome
extracellular space
filopodium
focal adhesion
phagocytic cup
plasma membrane
podosome
ruffle
ruffle membrane - Keywords:
- 3D-structure
Acetylation
Actin-binding
Alternative splicing
Calcium
Cell junction
Cell membrane
Cell projection
Chromosomal rearrangement
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat