Names & Taxonomy

Uniprot ID:
P13796
Entry Name:
PLSL_HUMAN
Status:
reviewed
Protein Names:
Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)
Gene Names:
LCP1 PLS2
Gene Names Primary:
LCP1
Organism:
Homo sapiens (Human)

Structure

Length:
627
Sequence:
MARGSVSDEEMMELREAFAKVDTDGNGYISFNELNDLFKAACLPLPGYRVREITENLMATGDLDQDGRISFDEFIKIFHGLKSTDVAKTFRKAINKKEGICAIGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTNDLFNAVGDGIVLCKMINLSVPDTIDERTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEELLLRWANYHLENAGCNKIGNFSTDIKDSKAYYHLLEQVAPKGDEEGVPAVVIDMSGLREKDDIQRAECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNRYPALHKPENQDIDWGALEGETREERTFRNWMNSLGVNPRVNHLYSDLSDALVIFQLYEKIKVPVDWNRVNKPPYPKLGGNMKKLENCNYAVELGKNQAKFSLVGIGGQDLNEGNRTLTLALIWQLMRRYTLNILEEIGGGQKVNDDIIVNWVNETLREAKKSSSISSFKDPKISTSLPVLDLIDAIQPGSINYDLLKTENLNDDEKLNNAKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLMGKGMKRV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton

Function

Function:
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
Gene Ontology Go:
actin cytoskeleton
actin filament
actin filament bundle
cytoplasm
cytosol
extracellular exosome
extracellular space
filopodium
focal adhesion
phagocytic cup
plasma membrane
podosome
ruffle
ruffle membrane
actin binding
actin filament binding
calcium ion binding
GTPase binding
actin filament bundle assembly
cell migration
extracellular matrix disassembly
organ regeneration
positive regulation of podosome assembly
protein kinase A signaling
regulation of intracellular protein transport
T cell activation involved in immune response
Gene Ontology Biological Process:
actin filament bundle assembly
cell migration
extracellular matrix disassembly
organ regeneration
positive regulation of podosome assembly
protein kinase A signaling
regulation of intracellular protein transport
T cell activation involved in immune response
Gene Ontology Molecular Function:
actin binding
actin filament binding
calcium ion binding
GTPase binding
Gene Ontology Cellular Component:
actin cytoskeleton
actin filament
actin filament bundle
cytoplasm
cytosol
extracellular exosome
extracellular space
filopodium
focal adhesion
phagocytic cup
plasma membrane
podosome
ruffle
ruffle membrane
Keywords:
3D-structure
Acetylation
Actin-binding
Alternative splicing
Calcium
Cell junction
Cell membrane
Cell projection
Chromosomal rearrangement
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat

Publication

PubMed ID:
2252891 14702039 15057823 15489334 3211125 2378651 8428952 2111166 3261603 10469447 15592455 16636079 17294403 19367720 19690332 19608861 21269460 21406692 24275569 25944712