Names & Taxonomy
- Uniprot ID:
- P13686
- Entry Name:
- PPA5_HUMAN
- Status:
- reviewed
- Protein Names:
- Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase)
- Gene Names:
- ACP5
- Gene Names Primary:
- ACP5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 325
- Sequence:
- MDMWTALLILQALLLPSLADGATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
- Catalytic Activity:
- A phosphate monoester + H(2)O = an alcohol + phosphate.
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875; ; Note=Binds 2 iron ions per subunit.;
- Cross Reference Drug Bank:
- DB02325
- Gene Ontology Go:
- cytosol
extracellular exosome
extracellular space
integral component of membrane
lysosome
acid phosphatase activity
ferric iron binding
ferrous iron binding
bone morphogenesis
bone resorption
defense response to Gram-positive bacterium
multicellular organismal response to stress
negative regulation of cell adhesion
negative regulation of inflammatory response
negative regulation of interleukin-1 beta production
negative regulation of interleukin-12 production
negative regulation of nitric oxide biosynthetic process
negative regulation of superoxide anion generation
negative regulation of tumor necrosis factor production
ossification
osteoclast differentiation
positive regulation of cell migration
response to cholesterol
response to cytokine
response to L-ascorbic acid
response to lipopolysaccharide
response to zinc ion
riboflavin metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- bone morphogenesis
bone resorption
defense response to Gram-positive bacterium
multicellular organismal response to stress
negative regulation of cell adhesion
negative regulation of inflammatory response
negative regulation of interleukin-12 production
negative regulation of interleukin-1 beta production
negative regulation of nitric oxide biosynthetic process
negative regulation of superoxide anion generation
negative regulation of tumor necrosis factor production
ossification
osteoclast differentiation
positive regulation of cell migration
response to cholesterol
response to cytokine
response to L-ascorbic acid
response to lipopolysaccharide
response to zinc ion
riboflavin metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- acid phosphatase activity
ferric iron binding
ferrous iron binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
extracellular space
integral component of membrane
lysosome - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hydrolase
Iron
Lysosome
Metal-binding
Polymorphism
Reference proteome
Signal