Names & Taxonomy
- Uniprot ID:
- P13591
- Entry Name:
- NCAM1_HUMAN
- Status:
- reviewed
- Protein Names:
- Neural cell adhesion molecule 1 (N-CAM-1) (NCAM-1) (CD antigen CD56)
- Gene Names:
- NCAM1 NCAM
- Gene Names Primary:
- NCAM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 858
- Sequence:
- MLQTKDLIWTLFFLGTAVSLQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSGLSTGAIVGILIVIFVLLLVVVDITCYFLNKCGLFMCIAVNLCGKAGPGAKGKDMEEGKAAFSKDESKEPIVEVRTEEERTPNHDGGKHTEPNETTPLTEPEKGPVEAKPECQETETKPAPAEVKTVPNDATQTKENESKA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cell membrane; Single-pass type I membrane protein.; Isoform 3: Cell membrane; Lipid-anchor, GPI-anchor.; Isoform 4: Cell membrane
Function
- Function:
- This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.; (Microbial infection) Acts as a receptor for rabies virus.
- Gene Ontology Go:
- anchored component of membrane
cell surface
cytoplasm
external side of plasma membrane
extracellular exosome
Golgi membrane
integral component of membrane
membrane
plasma membrane
identical protein binding
virus receptor activity
activation of MAPKK activity
axon guidance
cell adhesion
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
extracellular matrix organization
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interferon-gamma-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
regulation of synaptic plasticity
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
cell adhesion
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
extracellular matrix organization
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
interferon-gamma-mediated signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
Ras protein signal transduction
regulation of synaptic plasticity
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- identical protein binding
virus receptor activity - Gene Ontology Cellular Component:
- anchored component of membrane
cell surface
cytoplasm
external side of plasma membrane
extracellular exosome
Golgi membrane
integral component of membrane
membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
GPI-anchor
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunoglobulin domain
Lipoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix