Names & Taxonomy

Uniprot ID:
P13051
Entry Name:
UNG_HUMAN
Status:
reviewed
Protein Names:
Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
Gene Names:
UNG DGU UNG1 UNG15
Gene Names Primary:
UNG
Organism:
Homo sapiens (Human)

Structure

Length:
313
Sequence:
MIGQKTLYSFFSPSPARKRHAPSPEPAVQGTGVAGVPEESGDAAAIPAKKAPAGQEEPGTPPSSPLSAEQLDRIQRNKAAALLRLAARNVPVGFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQMCDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDIEDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVSWLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCRHFSKTNELLQKSGKKPIDWKEL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Mitochondrion.; Isoform 2: Nucleus.

Function

Function:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Catalytic Activity:
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
Active Site:
ACT_SITE 154 154 Proton acceptor.
Gene Ontology Go:
mitochondrion
nucleoplasm
nucleus
damaged DNA binding
uracil DNA N-glycosylase activity
base-excision repair
base-excision repair, AP site formation
depyrimidination
DNA repair
negative regulation of apoptotic process
positive regulation of isotype switching
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
viral process
Gene Ontology Biological Process:
base-excision repair
base-excision repair, AP site formation
depyrimidination
DNA repair
negative regulation of apoptotic process
positive regulation of isotype switching
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
viral process
Gene Ontology Molecular Function:
damaged DNA binding
uracil DNA N-glycosylase activity
Gene Ontology Cellular Component:
mitochondrion
nucleoplasm
nucleus
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
DNA damage
DNA repair
Direct protein sequencing
Disease mutation
Glycosidase
Host-virus interaction
Hydrolase
Mitochondrion
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Interacts With:
P15927

Publication

PubMed ID:
2555154 7926048 9016624 14702039 15489334 8332455 8670846 8551605 9753728 17081983 18676834 18220336 18669648 19413330 19690332 19608861 20068231 21406692 7697717 7671300 8900285 9724657 12958596 15967827