Names & Taxonomy

Uniprot ID:
P12955
Entry Name:
PEPD_HUMAN
Status:
reviewed
Protein Names:
Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase)
Gene Names:
PEPD PRD
Gene Names Primary:
PEPD
Organism:
Homo sapiens (Human)

Structure

Length:
493
Sequence:
MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFSGPK
Proteomes:
UP000005640

Function

Function:
Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
Catalytic Activity:
Hydrolysis of Xaa-|-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.
Cofactor:
COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Gene Ontology Go:
extracellular exosome
aminopeptidase activity
manganese ion binding
metallocarboxypeptidase activity
proline dipeptidase activity
cellular amino acid metabolic process
collagen catabolic process
proteolysis
Gene Ontology Biological Process:
cellular amino acid metabolic process
collagen catabolic process
proteolysis
Gene Ontology Molecular Function:
aminopeptidase activity
manganese ion binding
metallocarboxypeptidase activity
proline dipeptidase activity
Gene Ontology Cellular Component:
extracellular exosome
Keywords:
3D-structure
Acetylation
Alternative splicing
Collagen degradation
Complete proteome
Dipeptidase
Direct protein sequencing
Disease mutation
Hydrolase
Manganese
Metal-binding
Metalloprotease
Phosphoprotein
Polymorphism
Protease
Reference proteome
Interacts With:
P54274

Publication

PubMed ID:
2925654 14702039 15057824 15489334 11840567 19413330 21269460 22223895 24275569 2365824 8198124 8900231 12384772