Names & Taxonomy
- Uniprot ID:
- P12883
- Entry Name:
- MYH7_HUMAN
- Status:
- reviewed
- Protein Names:
- Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)
- Gene Names:
- MYH7 MYHCB
- Gene Names Primary:
- MYH7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1935
- Sequence:
- MGDSEMAVFGAAAPYLRKSEKERLEAQTRPFDLKKDVFVPDDKQEFVKAKIVSREGGKVTAETEYGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLPVYTPEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVLGFTSEEKNSMYKLTGAIMHFGNMKFKLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
Function
- Function:
- Muscle contraction.
- Gene Ontology Go:
- muscle myosin complex
myosin complex
myosin filament
sarcomere
stress fiber
Z disc
actin-dependent ATPase activity
ATP binding
ATPase activity
microfilament motor activity
adult heart development
ATP metabolic process
cardiac muscle contraction
muscle contraction
muscle filament sliding
regulation of heart rate
regulation of slow-twitch skeletal muscle fiber contraction
regulation of the force of heart contraction
regulation of the force of skeletal muscle contraction
skeletal muscle contraction
striated muscle contraction
transition between fast and slow fiber
ventricular cardiac muscle tissue morphogenesis - Gene Ontology Biological Process:
- adult heart development
ATP metabolic process
cardiac muscle contraction
muscle contraction
muscle filament sliding
regulation of heart rate
regulation of slow-twitch skeletal muscle fiber contraction
regulation of the force of heart contraction
regulation of the force of skeletal muscle contraction
skeletal muscle contraction
striated muscle contraction
transition between fast and slow fiber
ventricular cardiac muscle tissue morphogenesis - Gene Ontology Molecular Function:
- actin-dependent ATPase activity
ATPase activity
ATP binding
microfilament motor activity - Gene Ontology Cellular Component:
- muscle myosin complex
myosin complex
myosin filament
sarcomere
stress fiber
Z disc - Keywords:
- 3D-structure
ATP-binding
Actin-binding
Calmodulin-binding
Cardiomyopathy
Coiled coil
Complete proteome
Cytoplasm
Disease mutation
Isopeptide bond
Methylation
Motor protein
Muscle protein
Myosin
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Thick filament
Ubl conjugation - Interacts With:
- Q9BQD3
Publication
- PubMed ID:
- 2249844 2362820 10996847 15489334 2726733 8514894 2522082 3021460 1691980 2421254 3032769 2969919 3037493 8533830 16267253 16684601 18506004 18175163 20682791 21127202 25666907 1975517 1417858 1638703 1552912 8250038 8343162 8435239 8268932 8254035 8483915 7848441 7874131 8282798 7581410 7731997 8655135 8899546 10065021 9544842 9829907 9822100 10521296 10563488 10329202 10679957 10862102 11113006 11106718 11214007 11733062 11424919 11133230 12379228 12081993 11861413 11968089 14520662 12951062 12566107 12707239 12974739 12820698 12975413 12590187 12818575 15322983 15358028 15136674 15563892 15769782 15483641 15858117 16199542 15856146 16650083 16938236 17372140 17548557 17336526 18403758 21846512 25182012