Names & Taxonomy
- Uniprot ID:
- P12814
- Entry Name:
- ACTN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
- Gene Names:
- ACTN1
- Gene Names Primary:
- ACTN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 892
- Sequence:
- MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton
Function
- Function:
- F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
- Gene Ontology Go:
- brush border
cell projection
cell-cell junction
cytoplasm
cytosol
extracellular exosome
extracellular region
extracellular space
fascia adherens
focal adhesion
intracellular
plasma membrane
platelet alpha granule lumen
pseudopodium
ruffle
stress fiber
Z disc
actin filament binding
calcium ion binding
double-stranded RNA binding
integrin binding
ion channel binding
ligand-dependent nuclear receptor transcription coactivator activity
protein homodimerization activity
vinculin binding
actin crosslink formation
actin filament bundle assembly
actin filament network formation
actin filament organization
blood coagulation
cell junction assembly
extracellular matrix organization
focal adhesion assembly
negative regulation of cellular component movement
platelet activation
platelet degranulation
platelet formation
platelet morphogenesis
regulation of apoptotic process
regulation of nucleic acid-templated transcription - Gene Ontology Biological Process:
- actin crosslink formation
actin filament bundle assembly
actin filament network formation
actin filament organization
blood coagulation
cell junction assembly
extracellular matrix organization
focal adhesion assembly
negative regulation of cellular component movement
platelet activation
platelet degranulation
platelet formation
platelet morphogenesis
regulation of apoptotic process
regulation of nucleic acid-templated transcription - Gene Ontology Molecular Function:
- actin filament binding
calcium ion binding
double-stranded RNA binding
integrin binding
ion channel binding
ligand-dependent nuclear receptor transcription coactivator activity
protein homodimerization activity
vinculin binding - Gene Ontology Cellular Component:
- brush border
cell-cell junction
cell projection
cytoplasm
cytosol
extracellular exosome
extracellular region
extracellular space
fascia adherens
focal adhesion
intracellular
plasma membrane
platelet alpha granule lumen
pseudopodium
ruffle
stress fiber
Z disc - Keywords:
- 3D-structure
Acetylation
Actin-binding
Alternative splicing
Calcium
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat - Interacts With:
- B2R8Y4; P27958; Q7L775; Q8NC69; Q8IY33; Q9NPC6; P00973; Q8NA61; P12931; Q8VC66; Q8WZ42