Names & Taxonomy

Uniprot ID:
P12724
Entry Name:
ECP_HUMAN
Status:
reviewed
Protein Names:
Eosinophil cationic protein (ECP) (EC 3.1.27.-) (Ribonuclease 3) (RNase 3)
Gene Names:
RNASE3 ECP RNS3
Gene Names Primary:
RNASE3
Organism:
Homo sapiens (Human)

Structure

Length:
160
Sequence:
MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.

Function

Function:
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
Active Site:
ACT_SITE 42 42 Proton acceptor.; ACT_SITE 155 155 Proton donor.
Cross Reference Drug Bank:
DB01411
Gene Ontology Go:
extracellular exosome
extracellular region
extracellular space
endonuclease activity
nucleic acid binding
ribonuclease activity
antibacterial humoral response
defense response to Gram-positive bacterium
innate immune response in mucosa
nucleic acid phosphodiester bond hydrolysis
RNA catabolic process
RNA phosphodiester bond hydrolysis
Gene Ontology Biological Process:
antibacterial humoral response
defense response to Gram-positive bacterium
innate immune response in mucosa
nucleic acid phosphodiester bond hydrolysis
RNA catabolic process
RNA phosphodiester bond hydrolysis
Gene Ontology Molecular Function:
endonuclease activity
nucleic acid binding
ribonuclease activity
Gene Ontology Cellular Component:
extracellular exosome
extracellular region
extracellular space
Keywords:
3D-structure
Antibiotic
Antimicrobial
Complete proteome
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Hydrolase
Nitration
Nuclease
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
2473157 2387583 2745977 11102386 12508121 15489334 3458170 2501794 18694936 19450231 20690710 25944712 10606511 10903870 12356310