Names & Taxonomy
- Uniprot ID:
- P12318
- Entry Name:
- FCG2A_HUMAN
- Status:
- reviewed
- Protein Names:
- Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)
- Gene Names:
- FCGR2A CD32 FCG2 FCGR2A1 IGFR2
- Gene Names Primary:
- FCGR2A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 317
- Sequence:
- MTMETQMSQNVCPRNLWLLQPLTVLLLLASADSQAAAPPKAVLKLEPPWINVLQEDSVTLTCQGARSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIMLRCHSWKDKPLVKVTFFQNGKSQKFSHLDPTFSIPQANHSHSGDYHCTGNIGYTLFSSKPVTITVQVPSMGSSSPMGIIVAVVIATAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQLEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
- Cross Reference Drug Bank:
- DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00028 DB00075 DB00108 DB00110 DB00073 DB00081 DB00072
- Gene Ontology Go:
- extracellular exosome
integral component of membrane
plasma membrane
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response - Gene Ontology Biological Process:
- Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response - Gene Ontology Cellular Component:
- extracellular exosome
integral component of membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
IgG-binding protein
Immunity
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q9UMX0; Q9UMX0-2