Names & Taxonomy

Uniprot ID:
P12318
Entry Name:
FCG2A_HUMAN
Status:
reviewed
Protein Names:
Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)
Gene Names:
FCGR2A CD32 FCG2 FCGR2A1 IGFR2
Gene Names Primary:
FCGR2A
Organism:
Homo sapiens (Human)

Structure

Length:
317
Sequence:
MTMETQMSQNVCPRNLWLLQPLTVLLLLASADSQAAAPPKAVLKLEPPWINVLQEDSVTLTCQGARSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIMLRCHSWKDKPLVKVTFFQNGKSQKFSHLDPTFSIPQANHSHSGDYHCTGNIGYTLFSSKPVTITVQVPSMGSSSPMGIIVAVVIATAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQLEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
Cross Reference Drug Bank:
DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00028 DB00075 DB00108 DB00110 DB00073 DB00081 DB00072
Gene Ontology Go:
extracellular exosome
integral component of membrane
plasma membrane
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
Gene Ontology Biological Process:
Fc-gamma receptor signaling pathway involved in phagocytosis
innate immune response
Gene Ontology Cellular Component:
extracellular exosome
integral component of membrane
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
IgG-binding protein
Immunity
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Interacts With:
Q9UMX0; Q9UMX0-2

Publication

PubMed ID:
2824655 2529342 16710414 15489334 2965389 3402431 2526077 10397151 8327512 8132624 8756631 12690104 10331870 11397093 19011614 8636449