Names & Taxonomy
- Uniprot ID:
- P12236
- Entry Name:
- ADT3_HUMAN
- Status:
- reviewed
- Protein Names:
- ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]
- Gene Names:
- SLC25A6 ANT3 CDABP0051
- Gene Names Orf:
- CDABP0051
- Gene Names Primary:
- SLC25A6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 298
- Sequence:
- MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Multi-pass membrane protein. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria.
Function
- Function:
- Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
- Cross Reference Drug Bank:
- DB00720
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
mitochondrial inner membrane presequence translocase complex
mitochondrion
nucleus
ATP:ADP antiporter activity
structural constituent of ribosome
active induction of host immune response by virus
ADP transport
apoptotic process
ATP transport
cellular protein metabolic process
energy reserve metabolic process
modulation by virus of host morphology or physiology
protein targeting to mitochondrion
regulation of insulin secretion
small molecule metabolic process
translation
viral life cycle
viral process - Gene Ontology Biological Process:
- active induction of host immune response by virus
ADP transport
apoptotic process
ATP transport
cellular protein metabolic process
energy reserve metabolic process
modulation by virus of host morphology or physiology
protein targeting to mitochondrion
regulation of insulin secretion
small molecule metabolic process
translation
viral life cycle
viral process - Gene Ontology Molecular Function:
- ATP:ADP antiporter activity
structural constituent of ribosome - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
mitochondrial inner membrane presequence translocase complex
mitochondrion
nucleus - Keywords:
- Acetylation
Apoptosis
Complete proteome
Direct protein sequencing
Host-virus interaction
Membrane
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P63010; Q15323; Q5S007; Q9BRK4; Q9UJV3-2; Q5JR59; Q7Z3S9; Q8WW24; Q13077; P36406; Q15654