Names & Taxonomy
- Uniprot ID:
- P12235
- Entry Name:
- ADT1_HUMAN
- Status:
- reviewed
- Protein Names:
- ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4)
- Gene Names:
- SLC25A4 ANT1
- Gene Names Primary:
- SLC25A4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 298
- Sequence:
- MGDHAWSFLKDFLAGGVAAAVSKTAVAPIERVKLLLQVQHASKQISAEKQYKGIIDCVVRIPKEQGFLSFWRGNLANVIRYFPTQALNFAFKDKYKQLFLGGVDRHKQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKGAAQREFHGLGDCIIKIFKSDGLRGLYQGFNVSVQGIIIYRAAYFGVYDTAKGMLPDPKNVHIFVSWMIAQSVTAVAGLVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIAKDEGAKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane; Multi-pass membrane protein.
Function
- Function:
- Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.
- Cross Reference Drug Bank:
- DB00171 DB00720
- Gene Ontology Go:
- integral component of plasma membrane
mitochondrial inner membrane
mitochondrion
myelin sheath
nucleus
adenine transmembrane transporter activity
structural constituent of ribosome
adenine transport
apoptotic mitochondrial changes
energy reserve metabolic process
generation of precursor metabolites and energy
mitochondrial genome maintenance
negative regulation of necroptotic process
regulation of insulin secretion
small molecule metabolic process
translation
transport
viral process - Gene Ontology Biological Process:
- adenine transport
apoptotic mitochondrial changes
energy reserve metabolic process
generation of precursor metabolites and energy
mitochondrial genome maintenance
negative regulation of necroptotic process
regulation of insulin secretion
small molecule metabolic process
translation
transport
viral process - Gene Ontology Molecular Function:
- adenine transmembrane transporter activity
structural constituent of ribosome - Gene Ontology Cellular Component:
- integral component of plasma membrane
mitochondrial inner membrane
mitochondrion
myelin sheath
nucleus - Keywords:
- Acetylation
Cardiomyopathy
Complete proteome
Direct protein sequencing
Disease mutation
Host-virus interaction
Isopeptide bond
Membrane
Mitochondrion
Mitochondrion inner membrane
Progressive external ophthalmoplegia
Reference proteome
Repeat
S-nitrosylation
Transmembrane
Transmembrane helix
Transport
Ubl conjugation - Interacts With:
- Q5S007