Names & Taxonomy
- Uniprot ID:
- P12104
- Entry Name:
- FABPI_HUMAN
- Status:
- reviewed
- Protein Names:
- Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP)
- Gene Names:
- FABP2 FABPI
- Gene Names Primary:
- FABP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 132
- Sequence:
- MAFDSTWKVDRSENYDKFMEKMGVNIVKRKLAAHDNLKLTITQEGNKFTVKESSAFRNIEVVFELGVTFNYNLADGTELRGTWSLEGNKLIGKFKRTDNGNELNTVREIIGDELVQTYVYEGVEAKRIFKKD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
- Cross Reference Drug Bank:
- DB00783 DB01050 DB01138
- Gene Ontology Go:
- cytosol
fatty acid binding
transporter activity
digestion
small molecule metabolic process
triglyceride catabolic process - Gene Ontology Biological Process:
- digestion
small molecule metabolic process
triglyceride catabolic process - Gene Ontology Molecular Function:
- fatty acid binding
transporter activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Lipid-binding
Polymorphism
Reference proteome
Transport - Interacts With:
- O95994; Q9NYB0