Names & Taxonomy

Uniprot ID:
P12104
Entry Name:
FABPI_HUMAN
Status:
reviewed
Protein Names:
Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP)
Gene Names:
FABP2 FABPI
Gene Names Primary:
FABP2
Organism:
Homo sapiens (Human)

Structure

Length:
132
Sequence:
MAFDSTWKVDRSENYDKFMEKMGVNIVKRKLAAHDNLKLTITQEGNKFTVKESSAFRNIEVVFELGVTFNYNLADGTELRGTWSLEGNKLIGKFKRTDNGNELNTVREIIGDELVQTYVYEGVEAKRIFKKD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
Cross Reference Drug Bank:
DB00783 DB01050 DB01138
Gene Ontology Go:
cytosol
fatty acid binding
transporter activity
digestion
small molecule metabolic process
triglyceride catabolic process
Gene Ontology Biological Process:
digestion
small molecule metabolic process
triglyceride catabolic process
Gene Ontology Molecular Function:
fatty acid binding
transporter activity
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Lipid-binding
Polymorphism
Reference proteome
Transport
Interacts With:
O95994; Q9NYB0

Publication

PubMed ID:
2824476 15815621 15489334 14563446 10070036 14567680 9204553 12809489 7883976 12899384