Names & Taxonomy
- Uniprot ID:
- P12081
- Entry Name:
- SYHC_HUMAN
- Status:
- reviewed
- Protein Names:
- Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)
- Gene Names:
- HARS HRS
- Gene Names Primary:
- HARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 509
- Sequence:
- MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLCIC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance.
- Catalytic Activity:
- ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).
- Cross Reference Drug Bank:
- DB00117
- Gene Ontology Go:
- cytoplasm
cytosol
mitochondrion
ATP binding
histidine-tRNA ligase activity
gene expression
histidyl-tRNA aminoacylation
mitochondrial translation
translation
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- gene expression
histidyl-tRNA aminoacylation
mitochondrial translation
translation
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
histidine-tRNA ligase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
mitochondrion - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Charcot-Marie-Tooth disease
Complete proteome
Cytoplasm
Deafness
Disease mutation
Ligase
Neurodegeneration
Neuropathy
Nucleotide-binding
Phosphoprotein
Polymorphism
Protein biosynthesis
Reference proteome
Retinitis pigmentosa
Usher syndrome